CAS 106647-61-4

24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3

Description:

24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3, identified by its CAS number 106647-61-4, is a synthetic derivative of vitamin D3, which is crucial for calcium homeostasis and bone health. This compound features two fluorine atoms at the 24-position and a hydroxyl group at the 25-position, along with two methyl groups at the 26 and 27 positions of the steroid backbone. The introduction of fluorine atoms can enhance the compound's metabolic stability and alter its biological activity compared to natural vitamin D3. The hydroxyl group contributes to its solubility and potential interactions with vitamin D receptors. This compound is of interest in research for its potential therapeutic applications, particularly in conditions related to vitamin D deficiency or metabolic disorders. Its unique structural modifications may also influence its pharmacokinetics and pharmacodynamics, making it a subject of study in medicinal chemistry and endocrinology. As with other vitamin D analogs, its effects on calcium metabolism and bone health are key areas of investigation.

Formula: C₂₉H₄₆F₂O₂

InChI: InChI=1/C29H46F2O2/c1-6-28(33,7-2)29(30,31)18-16-21(4)25-14-15-26-22(9-8-17-27(25,26)5)11-12-23-19-24(32)13-10-20(23)3/h11-12,21,24-26,32-33H,3,6-10,13-19H2,1-2,4-5H3/b22-11+,23-12-/t21-,24+,25-,26?,27-/m1/s1

Synonyms:

• Dfdm-calcifediol
• (1S,3Z)-3-[(2E)-2-{(1R,7aR)-1-[(1R)-5-ethyl-4,4-difluoro-5-hydroxy-1-methylheptyl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexanol (non-preferred name)
• 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3