CAS 106730-54-5

Olprinone

Description:

Olprinone is a pharmacological agent primarily classified as a phosphodiesterase inhibitor, specifically targeting phosphodiesterase type 3 (PDE3). This compound is known for its vasodilatory and inotropic effects, making it useful in the treatment of heart failure and other cardiovascular conditions. Chemically, Olprinone is characterized by its ability to increase intracellular cyclic AMP levels, which enhances cardiac contractility and promotes vasodilation. It is typically administered intravenously and is noted for its relatively rapid onset of action. The substance is often studied for its potential benefits in improving cardiac output and reducing systemic vascular resistance. In terms of safety and side effects, Olprinone may cause hypotension, arrhythmias, or other cardiovascular effects, necessitating careful monitoring during administration. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for understanding its therapeutic applications and potential interactions with other medications. Overall, Olprinone represents a significant option in the management of acute heart failure and related conditions.

Formula: C₁₄H₁₀N₄O

InChI: InChI=1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19)

InChI key: InChIKey=JPAWFIIYTJQOKW-UHFFFAOYSA-N

SMILES: CC1=C(C2=CN3C(C=C2)=NC=C3)C=C(C#N)C(=O)N1

Synonyms:

• 1,2-Dihydro-5-Imidazo(1,2-Alpha)Pyridin-6-Yl-6-Methyl-2-Oxonicotinonitrile
• 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxonicotinonitrile
• 1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile
• 3-Pyridinecarbonitrile, 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
• 5-(1,7-Diazabicyclo[4.3.0]Nona-2,4,6,8-Tetraen-3-Yl)-6-Methyl-2-Oxo-1H-Pyridine-3-Carbonitrile
• 5-(Imidazo[1,2-A]Pyridin-6-Yl)-6-Methyl-2-Oxo-1,2-Dihydropyridine-3-Carbonitrile
• Imidazo[1,2-a]pyridine, 3-pyridinecarbonitrile deriv.
• Loprinone
• Olprinone(Loprinone)
• Olprinone

3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-

CAS: 106730-54-5

Formula: C₁₄H₁₀N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 250.2554

Ref: IN-DA00HAV0

Olprinone

CAS: 106730-54-5

Olprinone

Purity: 98%

Molecular weight: 250.26g/mol

Ref: 54-OR1026176

Olprinone

CAS: 106730-54-5

Olprinone

Purity: ≥98%

Molecular weight: 250.26g/mol

Ref: 54-BUP10377

Olprinone

CAS: 106730-54-5

Formula: C₁₄H₁₀N₄O

Molecular weight: 250.26

Ref: 7W-GP9168

Olprinone

CAS: 106730-54-5

Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate

Formula: C₁₄H₁₀N₄O

Purity: 99.68%

Color and Shape: Solid

Molecular weight: 250.26

Ref: TM-T5033

Olprinone

CAS: 106730-54-5

Formula: C₁₄H₁₀N₄O

Molecular weight: 250.26

Ref: 4Z-O-088001

5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

CAS: 106730-54-5

Purity: 95.0%

Molecular weight: 250.26100158691406

Ref: 10-F435175

Olprinone

CAS: 106730-54-5

Olprinone is a drug that is used to treat congestive heart failure. It is an oral medication that works by decreasing the workload of the heart and improving blood flow, which reduces the strain on the heart. Olprinone also decreases the production of cytokines such as IL-10 and TNF-α, which are associated with inflammation. This drug has been shown to be effective for treatment of skin cancer in a low-dose group. The molecular docking analysis showed that olprinone binds to a cardiac response element (CRE) in signal pathways. Olprinone has also been shown to have anti-inflammatory properties in vitro and in animal models.

Formula: C₁₄H₁₀N₄O

Purity: Min. 95%

Molecular weight: 250.26 g/mol

Ref: 3D-GEA73054