The chemical substance known as "2H-1-Benzopyran-2-one-5,6,7,8-d4, 4-hydroxy-" with CAS number 106754-18-1 is a deuterated derivative of coumarin, a compound characterized by its aromatic structure and presence of a lactone functional group. This specific compound features deuterium isotopes at positions 5, 6, 7, and 8 of the benzopyran ring, which can be useful in various applications, particularly in NMR spectroscopy for studying molecular dynamics and interactions. The presence of a hydroxy group at position 4 enhances its reactivity and solubility in polar solvents, making it a valuable compound in organic synthesis and medicinal chemistry. Coumarin derivatives are known for their diverse biological activities, including anticoagulant, anti-inflammatory, and antimicrobial properties. The deuterated form may also exhibit altered pharmacokinetics and metabolic pathways compared to its non-deuterated counterparts, making it an interesting subject for research in drug development and metabolic studies.

2H-1-Benzopyran-2-one-5,6,7,8-d4, 4-hydroxy-

106754-18-1: The chemical substance known as "2H-1-Benzopyran-2-one-5,6,7,8-d4, 4-hydroxy-" with CAS number 106754-18-1 is a deuterated derivative of coumarin, a compound characterized by its aromatic structure and presence of a lactone functional group. This specific compound features deuterium isotopes at positions 5, 6, 7, and 8 of the benzopyran ring, which can be useful in various applications, particularly in NMR spectroscopy for studying molecular dynamics and interactions. The presence of a hydroxy group at position 4 enhances its reactivity and solubility in polar solvents, making it a valuable compound in organic synthesis and medicinal chemistry. Coumarin derivatives are known for their diverse biological activities, including anticoagulant, anti-inflammatory, and antimicrobial properties. The deuterated form may also exhibit altered pharmacokinetics and metabolic pathways compared to its non-deuterated counterparts, making it an interesting subject for research in drug development and metabolic studies.

<p>Applications 4-Hydroxy Coumarin-d4 is the isotope labelled analog of 4-Hydroxy Coumarin (H924870); a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 integrase. 4-Hydroxy Coumarin-d4 is also a useful synthetic intermediate in the synthesis of 4’-Hydroxy Warfarin-d4 (H996102).<br>References Foti, M. et al.: J. Agric. F., 44, 497 (1996); J. Med. Chem., 40, 242 (1997)<br></p>

CAS 106754-18-1

2H-1-Benzopyran-2-one-5,6,7,8-d4, 4-hydroxy-

4-Hydroxy Coumarin-d4

Ref: TR-H924872