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CAS 106819-53-8

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Doxacurium chloride

Description:
Doxacurium chloride is a neuromuscular blocking agent primarily used in anesthesia to facilitate tracheal intubation and provide muscle relaxation during surgical procedures. It is classified as a non-depolarizing muscle relaxant, which means it works by competitively inhibiting the action of acetylcholine at the neuromuscular junction, thereby preventing muscle contraction. Doxacurium chloride has a relatively long duration of action compared to other agents in its class, making it suitable for procedures requiring extended muscle relaxation. It is typically administered intravenously and is known for its rapid onset of action. The substance is characterized by its quaternary ammonium structure, which contributes to its pharmacological properties and solubility in water. Side effects may include respiratory depression and cardiovascular effects, necessitating careful monitoring during administration. As with other neuromuscular blockers, the use of doxacurium chloride requires the availability of appropriate reversal agents and supportive care to manage potential complications.
Formula:C56H78N2O16·2Cl
InChI:InChI=1S/C56H78N2O16.2ClH/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6;;/h29-34,39-40H,15-28H2,1-14H3;2*1H/q+2;;/p-2
InChI key:InChIKey=APADFLLAXHIMFU-UHFFFAOYSA-L
SMILES:C(C1C=2C(=CC(OC)=C(OC)C2OC)CC[N+]1(CCCOC(CCC(OCCC[N+]3(C)C(CC4=CC(OC)=C(OC)C(OC)=C4)C=5C(CC3)=CC(OC)=C(OC)C5OC)=O)=O)C)C6=CC(OC)=C(OC)C(OC)=C6.[Cl-]
Synonyms:
  • (1R,2S
  • (1R,2S,1'S,2'R)-2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride
  • 1R*,2S*)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1)
  • 1S,2R)-1,2,3,4-Tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, succinate (2:1), mixture with (+-)-(1R*,2S*
  • BW A938U dichloride
  • Bis[3-[6,7,8-Trimethoxy-2-Methyl-1-[(3,4,5-Trimethoxyphenyl)Methyl]-3,4-Dihydro-1H-Isoquinolin-2-Ium-2-Yl]Propyl]Butanedioate Dichloride
  • Bw-A 938U
  • Chlorure de doxacurium
  • Cloruro de doxacurio
  • Doxacurii chloridum
  • See more synonyms
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