CAS 106861-44-3

Mivacurium chloride

Description:

Mivacurium chloride is a neuromuscular blocking agent primarily used in anesthesia to facilitate tracheal intubation and provide muscle relaxation during surgical procedures. It is a short-acting, non-depolarizing agent that works by competitively inhibiting the action of acetylcholine at the neuromuscular junction, leading to muscle paralysis. Mivacurium is characterized by its rapid onset and relatively short duration of action, which makes it particularly useful in situations where quick recovery of muscle function is desired. The substance is typically administered intravenously and is metabolized by plasma cholinesterase, resulting in a quick clearance from the body. Its chemical structure includes a quaternary ammonium group, contributing to its pharmacological properties. Mivacurium chloride is generally well-tolerated, but like all neuromuscular blockers, it may have side effects, including hypotension and allergic reactions. Careful monitoring of respiratory function is essential during its use, as it can lead to respiratory muscle paralysis.

Formula: C₅₈H₈₀N₂O₁₄·2Cl

InChI: InChI=1S/C58H80N2O14.2ClH/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10;;/h13-14,31-38,45-46H,15-30H2,1-12H3;2*1H/q+2;;/p-2/b14-13+;;/t45-,46-,59?,60?;;/m1../s1

InChI key: InChIKey=WMSYWJSZGVOIJW-ONUALHDOSA-L

SMILES: C([C@@H]1C=2C(=CC(OC)=C(OC)C2)CC[N+]1(CCCOC(CC/C=C/CCC(OCCC[N+]3(C)[C@H](CC4=CC(OC)=C(OC)C(OC)=C4)C=5C(CC3)=CC(OC)=C(OC)C5)=O)=O)C)C6=CC(OC)=C(OC)C(OC)=C6.[Cl-]

Synonyms:

• (1R,1'R)-2,2'-{[(4E)-1,8-Dioxooct-4-en-1,8-diyl]bis(oxypropan-3,1-diyl)}bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisochinolinium]dichlorid
• (1R,1'R)-2,2'-{[(4E)-1,8-Dioxooct-4-ene-1,8-diyl]bis(oxypropane-3,1-diyl)}bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride
• 2,2'-{[(4E)-1,8-dioxooct-4-ene-1,8-diyl]bis(oxypropane-3,1-diyl)}bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride
• BW B1090U Dichloride
• Bw-B 1090U
• Isoquinolinium, 2,2′-[(1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-, dichloride, [R-[R*,R*-(E)]]-
• Isoquinolinium, 2,2′-[[(4E)-1,8-dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-, chloride (1:2), (1R,1′R)-
• Isoquinolinium, 2,2′-[[(4E)-1,8-dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-, dichloride, (1R,1′R)-
• Mivacron
• [R-[R*,R*-(E)]]-2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium) Dichloride
• dichlorure de (1R,1'R)-2,2'-{[(4E)-1,8-dioxooct-4-ène-1,8-diyl]bis(oxypropane-3,1-diyl)}bis[6,7-diméthoxy-2-méthyl-1-(3,4,5-triméthoxybenzyl)-1,2,3,4-tétrahydroisoquinoléinium]
• isoquinolinium, 2,2'-[[(4E)-1,8-dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-, chloride, (1R,1'R)- (1:2)

Mivacurium chloride

CAS: 106861-44-3

Formula: C₅₈H₈₀Cl₂N₂O₁₄

Molecular weight: 1100.17

Ref: 7W-GP8968

Mivacurium dichloride

CAS: 106861-44-3

Mivacurium dichloride

Purity: ≥98%

Molecular weight: 1100.17g/mol

Ref: 54-BUP09754

Mivacurium Chloride (Mixture of Diastereomers)

CAS: 106861-44-3

Formula: C₅₈H₈₀N₂O₁₄·2Cl

Color and Shape: White To Off-White Solid

Molecular weight: 1029.28 2*35.45

Ref: 4Z-M-153001

Mivacurium Chloride (mixture of isomers)

CAS: 106861-44-3

Formula: C₅₈H₈₀Cl₂N₂O₁₄

Purity: >93.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 1,100.18

Ref: 3B-M2599

Mivacurium dichloride

CAS: 106861-44-3

Mivacurium dichloride: non-depolarizing, quick-acting muscle relaxant for minor surgeries and tracheal intubation.

Formula: C₅₈H₈₀Cl₂N₂O₁₄

Purity: 99.2% - 99.48%

Color and Shape: Off-White Solid

Molecular weight: 1100.17

Ref: TM-T22371

Mivacurium Chloride (mixture of isomers)

Controlled Product

CAS: 106861-44-3

Formula: C₅₈H₈₀N₂O₁₄·2Cl

Color and Shape: Neat

Molecular weight: 1100.17

Ref: TR-M385000

rac Mivacurium Chloride-13C4

Controlled Product

CAS: 106861-44-3

Stability Hygroscopic
Applications Non-depolarizing neuromuscular blocking agent. Muscle relaxant (skeletal).
References From, R.P., et al.: Br. J. Anaesth., 64, 193 (1990), Bevan, D.R., et al.: Pharmacol. Toxicol, 74, 3 (1994), Patel, S.S., et al.: Eur. J. Pharm. Sci., 5, 253 (1997), Boros, E.E., et al.: J. Med. Chem., 42, 206 (1999),

Formula: C₄C₅₄H₈₀N₂O₁₄

Color and Shape: Neat

Molecular weight: 1033.231

Ref: TR-M385002