CAS 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

Description:

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) is a phospholipid commonly used in biochemistry and pharmaceutical applications. It features two stearic acid chains, which contribute to its hydrophobic properties, and a phosphoethanolamine head group that imparts hydrophilicity. This amphiphilic nature allows DSPE to form lipid bilayers and micelles, making it valuable in drug delivery systems, particularly for encapsulating hydrophobic drugs. DSPE is known for its stability and ability to form liposomes, which are spherical vesicles that can encapsulate various substances. The compound is often utilized in the formulation of liposomal drugs and vaccines, enhancing the bioavailability and targeting of therapeutic agents. Additionally, DSPE can be modified to include polyethylene glycol (PEG) chains, improving circulation time and reducing immunogenicity. Its biocompatibility and versatility make it a crucial component in the development of nanocarriers for targeted drug delivery and gene therapy applications.

Formula: C₄₁H₈₂NO₈P

InChI: InChI=1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)/t39-/m1/s1

InChI key: InChIKey=LVNGJLRDBYCPGB-LDLOPFEMSA-N

SMILES: [C@@H](OC(CCCCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O

Synonyms:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(octadecanoyloxy)propyl octadecanoate
• (R)-Distearoylphosphatidylethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
• 3-{[(2-Aminoethoxy)(Hydroxy)Phosphoryl]Oxy}-2-(Octadecanoyloxy)Propyl Octadecanoate
• 64: PN: WO2017201317 SEQID: 137 claimed RNA
• <span class="text-smallcaps">L</span>-α-Distearoylphosphatidylethanolamine
• <span class="text-smallcaps">L</span>-β,γ-Distearoyl-α-phosphatidylethanolamine
• Coatsome ME 8080
• Distearoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• L-A-phosphatidylethanolamine,distearoyl
• Octadecanoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• Octadecanoic acid, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• Octadecanoic acid, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• Stearin, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• L-β,γ-Distearoyl-α-phosphatidylethanolamine

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

CAS: 1069-79-0

Formula: C₄₁H₈₂NO₈P

Purity: >97.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 748.08

Ref: 3B-D4214

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate

CAS: 1069-79-0

Formula: C₄₁H₈₂NO₈P

Purity: 97%

Color and Shape: Solid

Molecular weight: 748.0654

Ref: IN-DA007BD0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

Purity: ≥95%

Molecular weight: 748.07g/mol

Ref: 54-BUP18008

(2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Distearate

CAS: 1069-79-0

(2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Distearate

Purity: 95%

Molecular weight: 748.07g/mol

Ref: 54-OR1007966

1,2-Distearoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 1069-79-0

Formula: C41H82NO8P

Purity: >98%

Color and Shape: Solid

Molecular weight: 748.07

Ref: 48-37-1820

1,2-Distearoyl-SN-Glycero-3-Phosphoethanolamine

CAS: 1069-79-0

Formula: C₄₁H₈₂NO₈P

Molecular weight: 748.08

Ref: 4Z-P-312003

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) is a phosphatidylethanolamine (PE or GPEtn) capable of being used in the synthesis of liposomes.

Formula: C₄₁H₈₂NO₈P

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 748.07

Ref: TM-T5249

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

Purity: 98%

Molecular weight: 748.08

Ref: 10-F986827

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

Controlled Product

CAS: 1069-79-0

Applications 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine is used in the generation of micelles and liposomes.
References Høyrup, P., et al.: Biochim. Biophys. Acta, 1515, 133 (2001); Heberle, F., et al.: Cold Spring Harb Perspect Biol., 3, 1 (2011)

Formula: C₄₁H₈₂NO₈P

Color and Shape: Neat

Molecular weight: 748.07

Ref: TR-D493610

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine is an effector protein that functions to stabilize the extracellular matrix. It has been shown to be effective in the stabilization of lipid bilayers. This compound is a biocompatible polymer that can be used as a model system for studying dispersive solid phase extraction (DSPE). The phase transition temperature of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine is approximately -10°C. This property makes it suitable for use in applications where freeze/thaw cycles are required. The nitrogen atoms in this compound can react with alkanoic acids and liposomes to form stable complexes. These interactions are important pharmacokinetic properties of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine because they allow for the delivery of drugs into cells through

Formula: C₄₁H₈₂NO₈P

Purity: Min. 95%

Molecular weight: 748.07 g/mol

Ref: 3D-FD178397