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CAS 1069-79-0

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1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

Description:
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) is a phospholipid commonly used in biochemistry and pharmaceutical applications. It features two stearic acid chains, which contribute to its hydrophobic properties, and a phosphoethanolamine head group that imparts hydrophilicity. This amphiphilic nature allows DSPE to form lipid bilayers and micelles, making it valuable in drug delivery systems, particularly for encapsulating hydrophobic drugs. DSPE is known for its stability and ability to form liposomes, which are spherical vesicles that can encapsulate various substances. The compound is often utilized in the formulation of liposomal drugs and vaccines, enhancing the bioavailability and targeting of therapeutic agents. Additionally, DSPE can be modified to include polyethylene glycol (PEG) chains, improving circulation time and reducing immunogenicity. Its biocompatibility and versatility make it a crucial component in the development of nanocarriers for targeted drug delivery and gene therapy applications.
Formula:C41H82NO8P
InChI:InChI=1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)/t39-/m1/s1
InChI key:InChIKey=LVNGJLRDBYCPGB-LDLOPFEMSA-N
SMILES:[C@@H](OC(CCCCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O
Synonyms:
  • (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(octadecanoyloxy)propyl octadecanoate
  • (R)-Distearoylphosphatidylethanolamine
  • 1,2-Distearoyl-sn-glycero-3-phosphatidylethanolamine
  • 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
  • 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
  • 3-{[(2-Aminoethoxy)(Hydroxy)Phosphoryl]Oxy}-2-(Octadecanoyloxy)Propyl Octadecanoate
  • 64: PN: WO2017201317 SEQID: 137 claimed RNA
  • <span class="text-smallcaps">L</span>-α-Distearoylphosphatidylethanolamine
  • <span class="text-smallcaps">L</span>-β,γ-Distearoyl-α-phosphatidylethanolamine
  • Coatsome ME 8080
  • See more synonyms
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