CAS 106900-12-3

1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-

Description:

1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans- (CAS 106900-12-3) is a chemical compound characterized by its complex structure, which includes a piperidine ring, a butanamide moiety, and multiple aromatic substituents. The presence of a 4-chlorophenyl group and a hydroxyl group contributes to its potential biological activity and solubility properties. The dimethyl substitution on the nitrogen atom of the amide enhances its lipophilicity, which may influence its interaction with biological membranes. The compound's 1-oxide designation indicates the presence of an oxidized nitrogen atom, which can affect its reactivity and stability. This compound may exhibit pharmacological properties, making it of interest in medicinal chemistry. Its trans configuration suggests specific spatial arrangements of substituents, which can be crucial for its biological activity. Overall, this compound's unique structural features position it as a candidate for further research in drug development and related fields.

Formula: C₂₉H₃₃ClN₂O₃

InChI: InChI=1/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3

InChI key: InChIKey=KXVSBTJVTUVNPM-UKPNQBOSNA-N

SMILES: C(CCN1(=O)CC[C@@](O)(CC1)C2=CC=C(Cl)C=C2)(C(N(C)C)=O)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, 1-oxide, (E)-
• 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-
• 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
• Arestal
• Loperamide N-oxide
• Loperamide oxide [INN:BAN]
• Loperamide oxyde
• Loperamide oxyde [French]
• Loperamidum oxidum
• Loperamidum oxidum [Latin]
• Oxido de loperamida
• Oxido de loperamida [Spanish]
• R 58425
• trans-4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide 1-oxide
• trans-N-Oxide of loperamide
• Loperamide oxide
• DIPHENYLBUTANAMIDE HYDROCHLORIDE
• Loperamide EP Impurity F HCl
• LoperaMide-d6 N-Oxide
• 4-[TRANS-4-(4-CHLOROPHENYL)-4-HYDROXY-1-
• Loperamide N-oxideQ: What is
• Loperamide USP Related Compound F
• Loperamide N-oxide Q: What is the CAS Number of
• Loperamide N-oxide Q: What are the applications of
• Loperamide Impurity 6（Loperamide EP Impurity F）
• Loperamide N-oxide Q: What is the storage condition of
• Loperamide impurity-F(EP)
• Loperamide EP Impurity F
• trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide
• Loperamide Related Compound F ((1r,4s)-4-(4-Chlorophenyl)-1-[4-(dimethylamino)-4-oxo-3,3-diphenylbu (1370065)
• Loperamide EP Impurity F/ Loperamide Related Compound F (Loperamide N-Oxide)
• Loperamide oxide monohydrate CRS
• trans-Loperamide N-Oxide
• Loperamide Hydrochloride Impurity F
• OXIDOPIPERIDIN-1-YL]-N,N-DIMETHYL-2,2-
• Loperamide Hydrochloride EP Impurity F
• 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-oxide

LOPERAMIDE OXIDE MONOHYDRATE CRS

CAS: 106900-12-3

LOPERAMIDE OXIDE MONOHYDRATE CRS

Formula: C₂₉H₃₃ClN₂O₃

Color and Shape: White. Powder.

Molecular weight: 493.0369

Ref: 41-Y0000341

Loperamide N-oxide

CAS: 106900-12-3

Loperamide N-oxide

Color and Shape: Off-White

Ref: 47-636

Loperamide oxide

CAS: 106900-12-3

Loperamide oxide

Molecular weight: 493.04g/mol

Ref: 54-BUP14161

Loperamide EP Impurity F (Loperamide USP Related Compound F, trans-Loperamide N-Oxide)

CAS: 106900-12-3

Formula: C₂₉H₃₃ClN₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 493.04

Ref: 4Z-L-0910

Loperamide Oxide

Controlled Product

CAS: 106900-12-3

Formula: C₂₉H₃₃ClN₂O₃

Color and Shape: Neat

Molecular weight: 493.04

Ref: 86-MM0025.09

trans-Loperamide N-Oxide

Controlled Product

CAS: 106900-12-3

Stability Hygroscopic
Applications Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354 (1995), Hesselink, D., et al.: Clin. Pharmacol. Ther., 74, 245 (2003), Hooijberg, J., et al.: Biochem. Pharmacol., 67, 1541 (2004),

Formula: C₂₉H₃₃ClN₂O₃

Color and Shape: Off-White

Molecular weight: 493.04

Ref: TR-L469460

Loperamide N-oxide

CAS: 106900-12-3

μ-opioid receptor agonist; calcium channel inhibitor; anti-diarrheal

Formula: C₂₉H₃₃ClN₂O₃

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 493.04 g/mol

Ref: 3D-IL24926

Loperamide oxide

CAS: 106900-12-3

Loperamide oxide (R 58425) is a secreted antidiarrheal agent that increases peristalsis and inhibits intestinal absorption of water and ions.

Formula: C₂₉H₃₃ClN₂O₃

Color and Shape: Solid

Molecular weight: 493.04

Ref: TM-T25753