CAS 106941-25-7: Adefovir
Description:Adefovir is an antiviral medication primarily used in the treatment of chronic hepatitis B virus (HBV) infections. It is a nucleotide analogue of adenosine monophosphate and functions by inhibiting viral DNA polymerase, thereby preventing the replication of the virus. Adefovir is characterized by its chemical formula, which includes a phosphonate group, contributing to its mechanism of action. The substance is typically administered in oral form and is known for its relatively low resistance profile compared to other antiviral agents. Common side effects may include nephrotoxicity, which necessitates monitoring of renal function during treatment. Adefovir is also notable for its potential use in combination therapies, enhancing the efficacy of treatment regimens for HBV. Its pharmacokinetics indicate that it has a long half-life, allowing for once-daily dosing. Overall, Adefovir represents a significant option in the management of chronic hepatitis B, particularly for patients who may not respond to other treatments.
Formula:C8H12N5O4P
InChI:InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
InChI key:InChIKey=SUPKOOSCJHTBAH-UHFFFAOYSA-N
SMILES:O=P(O)(O)COCCN1C=NC=2C(=NC=NC21)N
- Synonyms:
- ((2-(6-Amino-9H-Purin-9-Yl)Ethoxy)Methyl)-Phosphonic Aci
- ((2-(6-Amino-9H-Purin-9-Yl)Ethoxy)Methyl)Phosphonic Acid
- ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonicacid
- 2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methylphosphonic Acid
- 2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid
- 2-(6-amino-7H-purin-9-yl)ethoxymethylphosphonic acid
- 9-[2-(Phosphono Methoxy)Ethyl]Adenine
- 9-[2-(Phosphonomethoxy)ethyl]adenine
- 9-[2-(Phosphonomethoxy)ethyl]adenine(PMEA)
- 9-[2-Phosphonylmethoxyethyl]Adenine
- See more synonyms
- Gs 0393
- P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid
- Phosphonic acid, P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
- Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
- Pmea
- [[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphoric acid
