CAS 107007-99-8

Granisetron Hydrochloride

Description:

Granisetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range typically between 4 and 6 when dissolved. The molecular formula of Granisetron Hydrochloride reflects its structure, which includes a piperidine ring, contributing to its pharmacological activity. This compound is often administered orally or intravenously, depending on the clinical scenario. Granisetron acts by blocking the action of serotonin at the 5-HT3 receptors in the gastrointestinal tract and the central nervous system, thereby inhibiting the vomiting reflex. Its pharmacokinetics indicate a relatively long half-life, allowing for effective management of nausea and vomiting with fewer doses. As with any medication, potential side effects may include headache, constipation, and dizziness, necessitating careful monitoring during treatment.

Formula: C₁₈H₂₄N₄O·ClH

InChI: InChI=1/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

InChI key: InChIKey=QYZRTBKYBJRGJB-WQTKJZBYNA-N

SMILES: C(N[C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])(=O)C=3C=4C(N(C)N3)=CC=CC4.Cl

Synonyms:

• 1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxamid
• 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl)-1H-Indazole-3-Carboxamide
• 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl)-1H-Indazole-3-Carboxamide Hydrochloride (1:1)
• 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide
• 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide Hydrochloride
• 1H-Indazole-3-Carboxamide, 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl)-, Monohydrochloride, Endo-
• 1H-Indazole-3-Carboxamide, 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-, Monohydrochloride
• 1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride (1:1)
• 9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv.
• Brl-43694A
• Brl-43694A, Kytril, 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide Hydrochloride
• Endo-1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxa
• Endo-Monohydrochlorid
• Endo-Monohydrochloride
• Granisertrol Hydrochloride
• Granisertronhydrochloride
• Granisetron Hcl
• Granisetron Hydrocholride
• Granisetronhclfda
• Granisetronhydrochloridefdainspected
• Granistron Hydrochloride
• Gransetron Hcl
• Kytril
• Midehydrochloride
• GranisetronBase

Granisetron Hydrochloride

CAS: 107007-99-8

Color and Shape: Neat

Ref: 61-FOR0398.00

GRANISETRON HYDROCHLORIDE CRS

CAS: 107007-99-8

GRANISETRON HYDROCHLORIDE CRS

Formula: C₁₈H₂₅ClN₄O

Color and Shape: White. Powder.

Molecular weight: 348.8703

Ref: 41-Y0000396

Granisetron Hydrochloride

CAS: 107007-99-8

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₈H₂₄N₄O·HCl

Color and Shape: White Off-White Powder

Molecular weight: 348.17169

Ref: 45-1298106

Granisetron hydrochloride

CAS: 107007-99-8

Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy

Formula: C₁₈H₂₅ClN₄O

Purity: 99.88% - 99.93%

Color and Shape: White To Off-White Crystalline Solid

Molecular weight: 348.87

Ref: TM-T1042

Granisetron hydrochloride

CAS: 107007-99-8

Formula: C₁₈H₂₄N₄O·HCl

Purity: 98.0 - 102.0 % (dried substance)

Color and Shape: White or almost white powder

Molecular weight: 348.87

Ref: 7W-GP3615

Granisetron hydrochloride, EP, USP grade

CAS: 107007-99-8

Formula: C₁₈H₂₄N₄O·HCl

Molecular weight: 348.87

Ref: 7W-GP9011

Granisetron HCl

CAS: 107007-99-8

Formula: C₁₈H₂₄N₄O·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 312.42 36.46

Ref: 4Z-G-073

Granisetron Hydrochloride

CAS: 107007-99-8, 109889-09-0

Formula: C₁₈H₂₄N₄O·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 348.88

Ref: 3B-G0401

Granisetron Hydrochloride

CAS: 107007-99-8

Color and Shape: Neat

Ref: 86-MM0398.00

Granisetron Hydrochloride

Controlled Product

CAS: 107007-99-8

Applications A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor
References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),

Formula: C₁₈H₂₄N₄O·ClH

Color and Shape: Neat

Molecular weight: 348.87

Ref: TR-G780000

Granisetron Hydrochloride

CAS: 107007-99-8

Formula: C₁₈H₂₄N₄OHCl

Molecular weight: 312.4 : 36.5

Ref: ST-EA-CP-G16011

Granisetron hydrochloride

Controlled Product

CAS: 107007-99-8

Serotonin receptor 5-HT3 antagonist

Formula: C₁₈H₂₅ClN₄O

Purity: Min. 95%

Color and Shape: Powder

Ref: 3D-FG23703