CAS 107015-83-8

amyloid B-protein fragment 12-28

Description:

Amyloid beta-protein fragment 12-28, associated with Alzheimer's disease, is a peptide derived from the amyloid precursor protein (APP). This fragment is significant in the study of amyloid plaques, which are characteristic of Alzheimer's pathology. The peptide consists of 17 amino acids and plays a role in the aggregation process that leads to the formation of amyloid fibrils. Its structure includes hydrophobic regions that facilitate interactions with other amyloid beta peptides, promoting oligomerization and fibril formation. The fragment is often studied for its neurotoxic effects, as it can disrupt cellular function and contribute to neurodegeneration. Additionally, it is used in research to understand the mechanisms of amyloid aggregation and the potential development of therapeutic strategies aimed at preventing or reversing the pathological processes associated with Alzheimer's disease. The CAS number 107015-83-8 uniquely identifies this specific peptide, allowing for precise reference in scientific literature and databases.

Formula: C₈₉H₁₃₅N₂₅O₂₅

Synonyms:

• Amyloid .beta.-Protein (12-28)
• H-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH

Amyloid β-Protein (12-28)

CAS: 107015-83-8

Injection of the amyloid β-protein fragment VHHQKLVFFAEDVGSNK into different limbic system structures in mice impaired retention with remarkably similar efficacy and in a dose-dependent manner. Aβ (12-28) and other Aβ fragments may exert dysregulatory cognitive effects by incoordination of K⁺ channel function in neurons, glia and endothelial cells.

Formula: C₈₉H₁₃₅N₂₅O₂₅

Purity: 96.4%

Color and Shape: White Lyophilisate

Molecular weight: 1955.2

Ref: 01-4014778

β-Amyloid (12-28)

CAS: 107015-83-8

Amyloid β-peptide fragment; minimum section required to bind to brain proteins.

Formula: C₈₉H₁₃₅N₂₅O₂₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 1955.18

Ref: TM-TP1227

Amyloid β-Protein (12-28)

CAS: 107015-83-8

Please enquire for more information about Amyloid beta-Protein (12-28) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₈₉H₁₃₅N₂₅O₂₅

Purity: Min. 95%

Molecular weight: 1,955.18 g/mol

Ref: 3D-FA110264