CAS 1070773-09-9

RK-33

CAS: 1070773-09-9

Formula: C₂₃H₂₀N₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 428.4433

Ref: IN-DA01ENVM

RK 33

CAS: 1070773-09-9

Formula: C₂₃H₂₀N₆O₃

Molecular weight: 428.45

Ref: 4Z-R-161001

RK33

CAS: 1070773-09-9

RK33

Purity: ≥95%

Molecular weight: 428.44g/mol

Ref: 54-BUP05962

RK 33-d6

CAS: 1070773-09-9

Formula: C₂₃H₁₄D₆N₆O₃

Molecular weight: 434.49

Ref: 4Z-R-161002

RK33

CAS: 1070773-09-9

"RK33 is a DDX3 inhibitor causing G1 arrest, apoptosis, and radiation sensitization in DDX3-overexpressing cells."

Formula: C₂₃H₂₀N₆O₃

Purity: 99.04% - 99.72%

Color and Shape: Solid

Molecular weight: 428.44

Ref: TM-T6970

RK 33

Controlled Product

CAS: 1070773-09-9

Applications RK 33 is an inhibitor of DDX3, an ATP-dependent RNA helicase (1). Aberrant regulation of DDX3 is related to various diseases such as prostate and breast cancer (2). RK 33 was shown to decrease proliferation of prostate cancer cells and induced a G1 phase cell-cycle arrest (2).
References (1) Botlagunta, M. et al.: PLoS One. 6, e17563 (2011) (2) Xie, M., et al.: Cancer Res. 76, 6340 (2016)

Formula: C₂₃H₂₀N₆O₃

Color and Shape: Neat

Molecular weight: 428.44

Ref: TR-R545500

RK-33

CAS: 1070773-09-9

RK-33 is a small molecule inhibitor, which is synthesized as a chemical compound. It functions by targeting and inhibiting the activity of DDX3, a DEAD-box RNA helicase, which plays a crucial role in the modulation of RNA biogenesis and translation processes. By interfering with DDX3, RK-33 disrupts processes essential for the proliferation of certain cancer cells, making it a significant focus in cancer research.

The compound demonstrates potential therapeutic applications in oncology, particularly in the treatment of cancers showing elevated DDX3 activity. Studies have shown its ability to impede the growth of tumor cells in various cancer models, highlighting its role in enhancing the efficacy of existing therapeutic strategies. Researchers are keenly investigating RK-33's effectiveness in combination therapies to better understand its potential in reducing tumor resistance and improving treatment outcomes. Such investigations could pave the way for developing targeted therapies across diverse types of malignancies where DDX3 is a pivotal factor.

Formula: C₂₃H₂₀N₆O₃

Purity: Min. 95%

Molecular weight: 428.44 g/mol

Ref: 3D-VSB77309