CAS 107233-08-9

Cevimeline

Description:

Cevimeline is a synthetic compound primarily used as a medication to treat dry mouth, particularly in patients with Sjögren's syndrome. It functions as a muscarinic agonist, selectively stimulating the M3 subtype of muscarinic acetylcholine receptors, which leads to increased salivary secretion. Cevimeline is characterized by its relatively high oral bioavailability and a moderate half-life, allowing for effective dosing regimens. The compound is typically administered in capsule form and is well-absorbed in the gastrointestinal tract. Common side effects may include sweating, nausea, and gastrointestinal discomfort, reflecting its cholinergic activity. Cevimeline's chemical structure includes a bicyclic framework, contributing to its pharmacological properties. As a therapeutic agent, it has been shown to improve the quality of life for individuals suffering from xerostomia (dry mouth), enhancing their ability to eat, speak, and maintain oral hygiene. Overall, Cevimeline represents a targeted approach to managing symptoms associated with salivary gland dysfunction.

Formula: C₁₀H₁₇NOS

InChI: InChI=1/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10-/s2

InChI key: InChIKey=WUTYZMFRCNBCHQ-CSEYRULYNA-N

SMILES: C[C@@H]1O[C@@]2([C@H]3CCN(C2)CC3)CS1

Synonyms:

• (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]
• (±)-cis-2-Methylspiro[1,3-oxathiolane-5,3′-quinuclidine]
• 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
• Af 102B
• Cevimeline [INN]
• Fks 508
• Hsdb 7286
• Sni 2011
• Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)-oxathiolane), 2'-methyl-, (2'R,3R)-rel-
• Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)-oxathiolane), 2'-methyl-, cis-
• Spiro[1-azabicyclo[2.2.2]octane-3,5′-[1,3]oxathiolane], 2′-methyl-, (2′R,3R)-rel-
• Unii-K9V0Cdq56E
• rel-(2′R,3R)-2′-Methylspiro[1-azabicyclo[2.2.2]octane-3,5′-[1,3]oxathiolane]

Cevimeline

CAS: 107233-08-9

Formula: C₁₀H₁₇NOS

Purity: 98%

Color and Shape: Solid

Molecular weight: 199.3131

Ref: IN-DA0082EW

Cevimeline

CAS: 107233-08-9

Cevimeline: muscarinic agonist, treats dry mouth & Sjögren's, boosts saliva post-cancer radiotherapy.

Formula: C₁₀H₁₇NOS

Color and Shape: Off-White Solid

Molecular weight: 199.31

Ref: TM-T21119