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CAS 107233-08-9

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Cevimeline

Description:
Cevimeline is a synthetic compound primarily used as a medication to treat dry mouth, particularly in patients with Sjögren's syndrome. It functions as a muscarinic agonist, selectively stimulating the M3 subtype of muscarinic acetylcholine receptors, which leads to increased salivary secretion. Cevimeline is characterized by its relatively high oral bioavailability and a moderate half-life, allowing for effective dosing regimens. The compound is typically administered in capsule form and is well-absorbed in the gastrointestinal tract. Common side effects may include sweating, nausea, and gastrointestinal discomfort, reflecting its cholinergic activity. Cevimeline's chemical structure includes a bicyclic framework, contributing to its pharmacological properties. As a therapeutic agent, it has been shown to improve the quality of life for individuals suffering from xerostomia (dry mouth), enhancing their ability to eat, speak, and maintain oral hygiene. Overall, Cevimeline represents a targeted approach to managing symptoms associated with salivary gland dysfunction.
Formula:C10H17NOS
InChI:InChI=1/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10-/s2
InChI key:InChIKey=WUTYZMFRCNBCHQ-CSEYRULYNA-N
SMILES:C[C@@H]1O[C@@]2([C@H]3CCN(C2)CC3)CS1
Synonyms:
  • (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]
  • (±)-cis-2-Methylspiro[1,3-oxathiolane-5,3′-quinuclidine]
  • 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
  • Af 102B
  • Cevimeline [INN]
  • Fks 508
  • Hsdb 7286
  • Sni 2011
  • Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)-oxathiolane), 2'-methyl-, (2'R,3R)-rel-
  • Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)-oxathiolane), 2'-methyl-, cis-
  • See more synonyms
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