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Ixazomib

CAS 1072833-77-2: Ixazomib

Description:Ixazomib is a small molecule proteasome inhibitor primarily used in the treatment of multiple myeloma. It functions by disrupting the proteasome's ability to degrade ubiquitinated proteins, leading to the accumulation of pro-apoptotic factors and ultimately inducing cancer cell death. Ixazomib is characterized by its oral bioavailability, making it a convenient option for patients compared to traditional intravenous therapies. The compound exhibits a specific mechanism of action that targets the 26S proteasome, which is crucial for regulating various cellular processes, including the cell cycle and apoptosis. Ixazomib is often used in combination with other therapies, such as lenalidomide and dexamethasone, to enhance its efficacy. Its pharmacokinetics involve metabolism primarily through the liver, with a half-life that supports once-weekly dosing. As with many cancer therapies, potential side effects may include thrombocytopenia, gastrointestinal disturbances, and peripheral neuropathy, necessitating careful monitoring during treatment. Overall, Ixazomib represents a significant advancement in the therapeutic landscape for multiple myeloma, providing an effective oral treatment option for patients.

Formula:C14H19BCl2N2O4

InChI:InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1

InChI key:InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N

SMILES:O=C(NCC(=O)NC(B(O)O)CC(C)C)C1=CC(Cl)=CC=C1Cl

  • Synonyms:
  • MLN 2238
  • B-[(1R)-1-[[2-[(2,5-Dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
  • Ninlaro
  • Boronic acid, B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-
  • Ixazomib
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Ixazomib

CAS:1072833-77-2

Ref: IN-DA0037YJ

1gTo inquire
5mg56.00 €
10mg100.00 €
25mg169.00 €
50mg181.00 €
100mg272.00 €
250mg598.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
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Ixazomib

CAS:1072833-77-2

Ref: 4Z-I-088001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Ref: 4Z-I-088002

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50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ixazomib [MLN2238]

CAS:1072833-77-2

Ref: 7W-GW1595

1mg106.00 €
5mg251.00 €
25mg720.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ixazomib

CAS:1072833-77-2

Ref: TM-T2122

1mg48.00 €
5mg95.00 €
10mg127.00 €
25mg279.00 €
50mg467.00 €
100mg653.00 €
500mg1,359.00 €
1mL*10mM (DMSO)97.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ixazomib-13C2,15N

Controlled Product
CAS:1072833-77-2

Ref: TR-I942002

1mg355.00 €
Estimated delivery in United States, on Friday 14 Mar 2025
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Ixazomib

CAS:1072833-77-2

Ref: 3D-FI65049

10mg262.00 €
25mg486.00 €
100mg1,043.00 €
250mg1,636.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
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Ixazomib

Controlled Product
CAS:1072833-77-2

Ref: TR-I942000

10mg242.00 €
50mg734.00 €
100mg1,190.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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