CAS 1072833-77-2: Ixazomib

Description: Ixazomib is a small molecule proteasome inhibitor primarily used in the treatment of multiple myeloma. It functions by disrupting the proteasome's ability to degrade ubiquitinated proteins, leading to the accumulation of pro-apoptotic factors and ultimately inducing cancer cell death. Ixazomib is characterized by its oral bioavailability, making it a convenient option for patients compared to traditional intravenous therapies. The compound exhibits a specific mechanism of action that targets the 26S proteasome, which is crucial for regulating various cellular processes, including the cell cycle and apoptosis. Ixazomib is often used in combination with other therapies, such as lenalidomide and dexamethasone, to enhance its efficacy. Its pharmacokinetics involve metabolism primarily through the liver, with a half-life that supports once-weekly dosing. As with many cancer therapies, potential side effects may include thrombocytopenia, gastrointestinal disturbances, and peripheral neuropathy, necessitating careful monitoring during treatment. Overall, Ixazomib represents a significant advancement in the therapeutic landscape for multiple myeloma, providing an effective oral treatment option for patients.

Formula: C₁₄H₁₉BCl₂N₂O₄

InChI: InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1

InChI key: InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N

SMILES: O=C(NCC(=O)NC(B(O)O)CC(C)C)C1=CC(Cl)=CC=C1Cl

Synonyms:

• MLN 2238
• B-[(1R)-1-[[2-[(2,5-Dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
• Ninlaro
• Boronic acid, B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-
• Ixazomib

Ixazomib

CAS: 1072833-77-2

• Formula: C₁₄H₁₉BCl₂N₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 361.0287

Ixazomib

CAS: 1072833-77-2

• Molecular weight: 361.03g/mol

Ixazomib

CAS: 1072833-77-2

• Purity: 98.07%
• Molecular weight: 361.03g/mol

Ixazomib

CAS: 1072833-77-2

• Formula: C₁₄H₁₉BCl₂N₂O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 361.03

Ixazomib [MLN2238]

CAS: 1072833-77-2

Ixazomib

CAS: 1072833-77-2

Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also …

• Formula: C₁₄H₁₉BCl₂N₂O₄
• Purity: 98% - 98.92%
• Color and Shape: Solid
• Molecular weight: 361.03

Ixazomib-d7

CAS: 1072833-77-2

• Formula: C₁₄H₁₂D₇BCl₂N₂O₄
• Molecular weight: 368.07

Ixazomib-13C2,15N

CAS: 1072833-77-2

Applications Ixazomib-13C2,15N is derived from (αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetic Acid Salt (P458505), which is a Bortezomib (B675700) …

• Formula: C₁₂₁₃C₂H₁₉BCl₂N₁₅NO₄
• Color and Shape: White To Off-White
• Molecular weight: 364.01

Ixazomib

CAS: 1072833-77-2

Proteosome inhibitor; antineoplastic

• Formula: C₁₄H₁₉BCl₂N₂O₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 361.03 g/mol

Ixazomib

CAS: 1072833-77-2

Applications Ixazomib is a proteasome inhibitor that acts by preventing cell growth in solid tumours. …

• Formula: C₁₄H₁₉BCl₂N₂O₄
• Color and Shape: Neat
• Molecular weight: 361.03