CAS 107316-88-1

Demethylzeylasteral

Description:

Demethylzeylasteral, with the CAS number 107316-88-1, is a chemical compound that belongs to the class of sterols, which are a subgroup of steroids. It is characterized by its complex polycyclic structure, which includes multiple fused rings typical of steroid compounds. This substance is primarily derived from natural sources, often isolated from plant materials, and is known for its potential biological activities, including anti-inflammatory and antioxidant properties. Demethylzeylasteral may also exhibit effects on lipid metabolism and has been studied for its potential therapeutic applications. Its solubility characteristics typically indicate that it is more soluble in organic solvents than in water, which is common for many sterols. The compound's stability and reactivity can be influenced by its functional groups and the presence of double bonds in its structure. As with many sterols, it may play a role in cellular processes and membrane dynamics, making it of interest in both pharmacological and biochemical research.

Formula: C₂₉H₃₆O₆

InChI: InChI=1S/C29H36O6/c1-25-6-7-26(2,24(34)35)14-21(25)29(5)11-9-27(3)17-12-19(32)23(33)16(15-30)22(17)18(31)13-20(27)28(29,4)10-8-25/h12-13,15,21,32-33H,6-11,14H2,1-5H3,(H,34,35)/t21-,25-,26-,27+,28-,29+/m1/s1

InChI key: InChIKey=ZDZSFWLPCFRASW-CPISFEQASA-N

SMILES: C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(O)=O)(C)C3)[H])CC[C@]4(C)C2=CC(=O)C=5C4=CC(O)=C(O)C5C=O

Synonyms:

• TZ 93
• Demethylzeylasteral
• (9β,13α,14β,20α)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid
• 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-
• D:A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-6,23-dioxo-, (20α)-

Demethylzeylasteral

CAS: 107316-88-1

Formula: C₂₉H₃₆O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 480.5925

Ref: IN-DA008Y1T

Demethylzeylasteral

CAS: 107316-88-1

Demethylzeylasteral

Purity: ≥98%

Molecular weight: 480.59g/mol

Ref: 54-BUP06528

Demethylzeylasteral

CAS: 107316-88-1

Formula: C₂₉H₃₆O₆

Molecular weight: 480.60

Ref: 7W-GY6323

Demethylzeylasteral (T-96)

CAS: 107316-88-1

Demethylzeylasteral (T-96)

Purity: 95%

Molecular weight: 480.59g/mol

Ref: 54-OR1024117

Demethylzeylasteral

CAS: 107316-88-1

Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7, and the inhibition kinetic parameters (Ki) are calculated to be 0.6 uM and 17.3 uM for UGT1A6 and UGT2B7, respectively. Demethylzeylasteral has antimicrobial, strong immunosuppressive, and antifertility activities; it concentration-dependently and in a partially reversible manner can inhibit the Ca(2+) current in spermatogenic cells with an IC(50) of 8.8 microg/ml, and it also can inhibit significantly the sperm acrosome reaction initiated by progesterone.

Formula: C₂₉H₃₆O₆

Purity: 95%~99%

Molecular weight: 480.601

Ref: BP-BP0477

Demethylzeylasteral

CAS: 107316-88-1

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities.

Formula: C₂₉H₃₆O₆

Purity: 98.74% - 99.82%

Color and Shape: Solid

Molecular weight: 480.59

Ref: TM-T3418

Demethylzeylasteral

CAS: 107316-88-1

Carboxylic acid with additional oxygen functions

Formula: C₂₉H₃₆O₆

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 480.6

Ref: 5G-83493

Demethylzeylasteral

Controlled Product

CAS: 107316-88-1

Applications Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.
References Xu, M., et al.: Anal. Chem., 88, 8050-8057 (2016); An, H., et al.: Cell Biochem. Biophys., 73, 673-679 (2015)

Formula: C₂₉H₃₆O₆

Color and Shape: Neat

Molecular weight: 480.59

Ref: TR-D231408

Demethylzeylasteral

Controlled Product

CAS: 107316-88-1

Demethylzeylasteral is a drug that has been shown to have significant cytotoxicity against du-145 cells and may be used as an experimental model for autoimmune diseases. The drug has shown clinical relevance in vitro assays, where it was found to inhibit the proliferation of glomerular cells and induce mitochondrial membrane potential loss. Demethylzeylasteral also appears to have significant interactions with other drugs, such as lc-ms/ms method. This drug is a chinese herb that has been shown to increase autophagy and decrease metabolic disorders in animal models.

Formula: C₂₉H₃₆O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 480.59 g/mol

Ref: 3D-FD73925