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CAS 107348-47-0

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N-succinimidyl-3-(2-pyridyldithio)butyrate

Description:
N-succinimidyl-3-(2-pyridyldithio)butyrate, commonly referred to as SPDB, is a chemical compound characterized by its reactive succinimidyl ester functional group, which facilitates the formation of stable amide bonds with nucleophiles, such as amino groups in proteins. This compound features a 2-pyridyldithio moiety, which is significant for its ability to form disulfide bonds, making it useful in bioconjugation applications. SPDB is often employed in the modification of biomolecules, allowing for the selective attachment of labels or other functional groups to proteins, peptides, or other macromolecules. The presence of the dithio group enables the formation of covalent linkages that can be utilized in various biochemical assays and therapeutic applications. Additionally, SPDB is typically soluble in organic solvents, which aids in its application in laboratory settings. Its reactivity and specificity make it a valuable tool in the fields of biochemistry and molecular biology for the development of targeted drug delivery systems and the study of protein interactions.
Formula:C13H14N2O4S2
InChI:InChI=1/C13H14N2O4S2/c1-9(20-21-10-4-2-3-7-14-10)8-13(18)19-15-11(16)5-6-12(15)17/h2-4,7,9H,5-6,8H2,1H3
SMILES:CC(CC(=O)ON1C(=O)CCC1=O)SSc1ccccn1
Synonyms:
  • 1-(1-Oxo-3-(2-pyridinyldithio)butoxy)-2,5-pyrrolidinedione
  • Spdb
  • 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)butoxy)-
  • 1-{[3-(Pyridin-2-Yldisulfanyl)Butanoyl]Oxy}Pyrrolidine-2,5-Dione
  • N-Succinimidyl-3-(2-pyridyldithio)butyrate
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