TD-0212 (TFA), with the CAS number 1073549-11-7, is a chemical compound that belongs to a class of substances known for their potential applications in medicinal chemistry and pharmacology. While specific characteristics such as molecular weight, boiling point, and solubility may vary, compounds in this category typically exhibit properties that make them suitable for biological activity. TD-0212 (TFA) is often characterized by its ability to interact with biological targets, potentially influencing various physiological processes. The presence of trifluoroacetic acid (TFA) in its name suggests that it may possess unique solubility and stability characteristics, particularly in organic solvents. Additionally, compounds like TD-0212 are often evaluated for their efficacy, safety, and pharmacokinetic profiles in drug development. As with any chemical substance, handling and usage should adhere to safety guidelines to mitigate any risks associated with its chemical properties. Further research and data are essential to fully understand its behavior and applications in scientific and medical contexts.

TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
TD-0212 provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition[1].
TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension[1].

TD-0212 (TFA)

1073549-11-7: TD-0212 (TFA), with the CAS number 1073549-11-7, is a chemical compound that belongs to a class of substances known for their potential applications in medicinal chemistry and pharmacology. While specific characteristics such as molecular weight, boiling point, and solubility may vary, compounds in this category typically exhibit properties that make them suitable for biological activity. TD-0212 (TFA) is often characterized by its ability to interact with biological targets, potentially influencing various physiological processes. The presence of trifluoroacetic acid (TFA) in its name suggests that it may possess unique solubility and stability characteristics, particularly in organic solvents. Additionally, compounds like TD-0212 are often evaluated for their efficacy, safety, and pharmacokinetic profiles in drug development. As with any chemical substance, handling and usage should adhere to safety guidelines to mitigate any risks associated with its chemical properties. Further research and data are essential to fully understand its behavior and applications in scientific and medical contexts.

<p>TD-0212 is a potent activator of TRPV1 receptors. It is an agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel, which is expressed in sensory neurons and peripheral nerve fibers. TD-0212 is useful for pharmacological research to study TRPV1 receptor activity in the central nervous system and for use as a research tool to investigate protein interactions.</p>

<p>TD-0212 TFA is an oral AT1 receptor antagonist &amp; NEP inhibitor with pKi 8.9 &amp; pIC50 9.2.</p>

CAS 1073549-11-7

TD-0212 (TFA)

TD-0212 (TFA)

Ref: 3D-YSB54911

TD-0212 TFA

Ref: TM-T13125L