CAS 107381-35-1

(R)-Propafenone hydrochloride

Description:

(R)-Propafenone hydrochloride is a pharmaceutical compound primarily used as an antiarrhythmic agent for the treatment of certain types of cardiac arrhythmias. It is a chiral molecule, with the (R)-enantiomer being the active form that exhibits therapeutic effects. The substance is characterized by its ability to block sodium channels, which helps to stabilize cardiac electrical activity and restore normal heart rhythm. In its hydrochloride salt form, it is typically a white to off-white crystalline powder that is soluble in water and exhibits a moderate melting point. The compound has a relatively low bioavailability due to extensive first-pass metabolism, necessitating careful dosing and monitoring in clinical settings. Additionally, (R)-Propafenone hydrochloride may interact with various cytochrome P450 enzymes, influencing the metabolism of other drugs. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for understanding its efficacy and safety profile in patients with arrhythmias.

Formula: C₂₁H₂₇NO₃·ClH

InChI: InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H/t18-;/m1./s1

InChI key: InChIKey=XWIHRGFIPXWGEF-GMUIIQOCSA-N

SMILES: O(C[C@@H](CNCCC)O)C1=C(C(CCC2=CC=CC=C2)=O)C=CC=C1.Cl

Synonyms:

• (R)-Propafenone hydrochloride
• 1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride, (R)-
• 1-Propanone, 1-[2-[(2R)-2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride
• Lu 44215

(R)-Propafenone HCl

CAS: 107381-35-1

Formula: C₂₁H₂₇NO₃·HCl

Molecular weight: 341.45 36.46

Ref: 4Z-P-1528