CAS 107452-89-1

omega-conotoxin mviia

Description:

Omega-conotoxin MVIIA is a peptide derived from the venom of the marine cone snail, Conus magus. It is classified as a neurotoxin and is known for its potent ability to selectively block N-type voltage-gated calcium channels (VGCCs), which play a crucial role in neurotransmitter release and pain signaling. This characteristic makes omega-conotoxin MVIIA a subject of interest in pain management research and potential therapeutic applications. The peptide consists of 25 amino acids and features a unique structure stabilized by disulfide bonds, contributing to its stability and specificity. Its mechanism of action involves binding to the calcium channels, inhibiting calcium influx, and thereby reducing neurotransmitter release, which can alleviate pain sensations. Omega-conotoxin MVIIA has been studied for its potential use in treating chronic pain conditions and has implications in neuroscience research, particularly in understanding pain pathways and synaptic transmission. As a research compound, it is often utilized in pharmacological studies to explore its effects on neuronal activity and pain modulation.

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

InChI: InChI=1/C102H172N36O32S7/c1-50(2)34-63-91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(21-15-32-114-102(111)112)126-96(166)70-46-176-177-47-71(97(167)132-68(43-141)95(165)125-60(87(157)128-63)20-14-31-113-101(109)110)134-89(159)59(19-9-13-30-106)123-81(151)51(3)119-74(144)37-115-83(153)56(16-6-10-27-103)120-75(145)38-116-84(154)57(17-7-11-28-104)124-82(152)55(107)44-172-174-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)

SMILES: CC(C)CC1C(=NC(CCSC)C(=NC(Cc2ccc(cc2)O)C(=NC(CC(=O)O)C(=NC2CSSCC(C(=N)O)N=C(C(CCCCN)N=C(CN=C(C(CO)N=C(C(CCCNC(=N)N)N=C(C3CSSCC(C(=NC(CO)C(=NC(CCCNC(=N)N)C(=N1)O)O)O)N=C(C(CCCCN)N=C(C(C)N=C(CN=C(C(CCCCN)N=C(CN=C(C(CCCCN)N=C(C(CSSCC(C(=NC(C(C)O)C(=NCC(=NC(CO)C(=N3)O)O)O)O)N=C2O)N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Synonyms:

• Conotoxin MVIIA
• H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys25)
• Ziconotide
• Ziconotide Acetate

ω-Conotoxin MVIIA

CAS: 107452-89-1

ω-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitive Ca²⁺ channels in neurons. The peptide has been used to identify different Ca²⁺ channel subtypes in amphibian brain.

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Purity: ≥ 97%

Color and Shape: White Powder

Molecular weight: 2639.17

Ref: 01-4025279

ω-Conotoxin MVIIA

CAS: 107452-89-1

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Purity: (HPLC) ≥ 97.0%

Color and Shape: White powder

Molecular weight: 2639.13

Ref: 7W-GK7741

Ziconotide

CAS: 107452-89-1

Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Purity: 98%

Color and Shape: White Powder

Molecular weight: 2639.13

Ref: TM-TP1559

Ziconotide

CAS: 107452-89-1

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇·C₂H₄O₂

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 2699.18

Ref: BP-BPPG070

Ziconotide Acetate

CAS: 107452-89-1

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Molecular weight: 2639.20

Ref: 4Z-PZ-046001

Omega-Conotoxin MVIIA

CAS: 107452-89-1

Omega-conotoxin MVIIA is a peptide that is an activator of voltage-gated calcium channels. It is an inhibitor of the L-type calcium channel and can be used to study protein interactions in cell biology. Omega-conotoxin MVIIA has been shown to have binding affinity for the nicotinic acetylcholine receptor, which belongs to the class of ligand-gated ion channels. This toxin has also been used as a research tool in pharmacology and antibody production. Omega-conotoxin MVIIA has a molecular weight of 3,411 daltons, with purity greater than 95%. CAS No. 107452-89-1

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Purity: Min. 95%

Molecular weight: 2,639.1 g/mol

Ref: 3D-PCN-4289-V

Omega-Conotoxin MVIIA

Controlled Product

CAS: 107452-89-1

Omega-Conotoxin MVIIA is a neurotoxin that inhibits voltage-dependent calcium channels and has been shown to be effective against neuropathic pain, chronic pain, and inflammatory pain. The long-term efficacy of this drug is due to its ability to block cytosolic calcium, which leads to the activation of neurotrophic factors. Omega-Conotoxin MVIIA binds to specific protein targets and inhibits ion channel activity in neurons. This toxin can also inhibit the production of proinflammatory cytokines by blocking the activation of NF-κB through intracellular targets. Omega-Conotoxin MVIIA has been shown to have a wide range of therapeutic potentials, including as an analgesic for acute and chronic pain, as an anti-inflammatory agent, and as a neuroprotective agent for treating neuronal degeneration.

Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Purity: Min. 95%

Molecular weight: 2,639.14 g/mol

Ref: 3D-FC110295