CAS 1074549-89-5

Apixaban Dehydro Impurity

Description:

Apixaban Dehydro Impurity, identified by the CAS number 1074549-89-5, is a chemical compound associated with the anticoagulant drug apixaban, which is used to prevent blood clots. This impurity arises during the synthesis or degradation of apixaban and is characterized by its structural modifications that typically involve the loss of hydrogen atoms, leading to a dehydrogenated form of the parent compound. The presence of such impurities is significant in pharmaceutical formulations, as they can affect the drug's efficacy and safety profile. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are often employed to identify and quantify impurities like this one. Understanding the characteristics of Apixaban Dehydro Impurity, including its stability, solubility, and potential biological activity, is crucial for ensuring the quality and safety of apixaban-containing medications. Regulatory guidelines typically require thorough characterization of impurities to assess their impact on drug performance and patient health.

Formula: C₂₅H₂₃N₅O₄

Synonyms:

• Apixaban impurity 11/4,5-Dehydro Apixaban/Apixaban dehydro Impurity/1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
• Apixaban Impurity TQ
• 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
• Dehydro Apixaban
• Apixaban 4,5-Dehydro Carboxamide
• 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
• 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 6,7-dihydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-
• Apixaban 4,5-Dehydro Imp
• 6,7-Dihydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl) phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
• Apixaban Dehydro Impurity
• Apixaban 4,5-Dehydro Impurity

Apixaban Impurity 35

CAS: 1074549-89-5

Formula: C₂₅H₂₃N₅O₄

Color and Shape: Off-White Solid

Molecular weight: 457.49

Ref: 4Z-A-10222

4,5-Dehydro Apixaban

Controlled Product

CAS: 1074549-89-5

Applications 4,5-Dehydro Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)

Formula: C₂₅H₂₃N₅O₄

Color and Shape: Neat

Molecular weight: 457.48

Ref: TR-D229385

Apixaban Impurity 35

CAS: 1074549-89-5

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Formula: C₂₅H₂₃N₅O₄

Purity: Min. 95%

Molecular weight: 457.48 g/mol

Ref: 3D-FA173288

4,5-Dehydro Apixaban

CAS: 1074549-89-5

Formula: C₂₅H₂₃N₅O₄

Molecular weight: 457.49

Ref: ST-EA-CP-A3071