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CAS 107648-80-6

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Cefepime hydrochloride

Description:
Cefepime hydrochloride is a broad-spectrum cephalosporin antibiotic, classified as a fourth-generation cephalosporin. It is primarily used to treat a variety of bacterial infections, particularly those caused by Gram-negative and some Gram-positive bacteria. The compound is characterized by its ability to inhibit bacterial cell wall synthesis, which is crucial for bacterial growth and replication. Cefepime is typically administered via injection and is known for its stability against certain beta-lactamases, making it effective against resistant strains. The hydrochloride form enhances its solubility in water, facilitating its use in clinical settings. In terms of physical properties, cefepime hydrochloride is a white to pale yellow crystalline powder. It is generally well-tolerated, but like all antibiotics, it may cause side effects, including allergic reactions and gastrointestinal disturbances. Its pharmacokinetics involve renal excretion, necessitating dosage adjustments in patients with impaired kidney function. Overall, cefepime hydrochloride is a valuable therapeutic agent in the management of serious infections.
Formula:C19H26Cl2N6O5S2
InChI:InChI=1/C19H24N6O5S2.2ClH/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;;/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29);2*1H/b23-12-;;/t13-,17-;;/m1../s1
SMILES:C[N+]1(CCCC1)CC1=C(C(=O)[O-])N2C(=O)[C@H]([C@H]2SC1)N=C(/C(=N\OC)/c1csc(=N)[nH]1)O.Cl.Cl
Synonyms:
  • Cefepim dihydrochloride
  • Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride, monohydrochloride, monohydrate
  • Pyrrolidinium, 1-[[7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride, monohydrochloride, [6R-[6α,7β(Z)]]-
  • (6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-[1-(1-methylpyrrolidinyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid hydrochloride
  • Cefepime Hydrochloride (Buffered With Arginine)
  • 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl- pyrrolidinium Inner Salt Hydrochloride
  • Axepim
  • Cefepime dihydrochloride
  • Cefepime hcl
  • 1-{[(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidinium chloride hydrochloride
  • Cefeprime Dihydrochloride
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