CAS 107724-20-9

(+)-Eplerenone

Description:

(+)-Eplerenone is a synthetic steroid and a selective aldosterone antagonist, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to block the effects of aldosterone, a hormone that regulates sodium and potassium levels in the body, thereby promoting diuresis and reducing blood pressure. The compound has a unique molecular structure that includes a lactone ring and a spiro structure, contributing to its specificity and potency. (+)-Eplerenone exhibits good oral bioavailability and is metabolized primarily in the liver, with a half-life that allows for once-daily dosing. Its pharmacological profile includes a favorable side effect profile compared to other diuretics, with a lower incidence of hyperkalemia. Additionally, it has been shown to improve outcomes in patients with heart failure post-myocardial infarction. Overall, (+)-Eplerenone represents an important therapeutic option in cardiovascular medicine, particularly for patients with conditions related to excess aldosterone.

Formula: C₂₄H₃₀O₆

InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key: InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N

SMILES: C[C@@]12[C@]34[C@]([C@]5([C@](C)(C[C@]3(O4)[H])[C@@]6(CC5)CCC(=O)O6)[H])([C@H](C(OC)=O)CC1=CC(=O)CC2)[H]

Synonyms:

• Cgp 30083
• Epoxymexrenone
• Inspra
• Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
• Sc 6110
• Sc 66110
• Selara
• Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
• The Intermediates
• methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

Eplerenone

CAS: 107724-20-9

Aldosterone blocker

Formula: C₂₄H₃₀O₆

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 414.49 g/mol

Ref: 3D-FP22747