CAS 107724-20-9

(+)-Eplerenone

Description:

(+)-Eplerenone is a synthetic steroid and a selective aldosterone antagonist, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to block the effects of aldosterone, a hormone that regulates sodium and potassium levels in the body, thereby promoting diuresis and reducing blood pressure. The compound has a unique molecular structure that includes a lactone ring and a spiro structure, contributing to its specificity and potency. (+)-Eplerenone exhibits good oral bioavailability and is metabolized primarily in the liver, with a half-life that allows for once-daily dosing. Its pharmacological profile includes a favorable side effect profile compared to other diuretics, with a lower incidence of hyperkalemia. Additionally, it has been shown to improve outcomes in patients with heart failure post-myocardial infarction. Overall, (+)-Eplerenone represents an important therapeutic option in cardiovascular medicine, particularly for patients with conditions related to excess aldosterone.

Formula: C₂₄H₃₀O₆

InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key: InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N

SMILES: C[C@@]12[C@]34[C@]([C@]5([C@](C)(C[C@]3(O4)[H])[C@@]6(CC5)CCC(=O)O6)[H])([C@H](C(OC)=O)CC1=CC(=O)CC2)[H]

Synonyms:

• Cgp 30083
• Epoxymexrenone
• Inspra
• Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
• Sc 6110
• Sc 66110
• Selara
• Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
• The Intermediates
• methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

Eplerenone - Bio-X ™

CAS: 107724-20-9

Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. It does this by blocking the activity of the enzyme that produces aldosterone, which increases levels of sodium and water in the body. This leads to a decrease in blood pressure.

Formula: C₂₄H₃₀O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 414.49 g/mol

Ref: 3D-BE164415