CAS 107761-24-0

2-Cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-2-propenamide

Description:

2-Cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-2-propenamide, with CAS number 107761-24-0, is a synthetic organic compound characterized by its complex molecular structure, which includes a cyano group, an amide functional group, and multiple aromatic rings. This compound features a phenylthio group, which contributes to its potential biological activity and solubility properties. The presence of the ethoxy and hydroxy substituents enhances its reactivity and may influence its interactions in biological systems. Typically, compounds of this nature are studied for their potential applications in pharmaceuticals, particularly in the development of drugs targeting specific biological pathways. The structural features suggest that it may exhibit interesting chemical properties, such as the ability to form hydrogen bonds and engage in π-π stacking interactions, which are relevant in medicinal chemistry. As with many organic compounds, its stability, solubility, and reactivity can be influenced by environmental factors such as pH and temperature.

Formula: C₁₉H₁₈N₂O₃S

InChI: InChI=1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)

InChI key: InChIKey=YKLMGKWXBLSKPK-UHFFFAOYSA-N

SMILES: C(=C(C(N)=O)C#N)C1=CC(CSC2=CC=CC=C2)=C(O)C(OCC)=C1

Synonyms:

• (2E)-2-cyano-3-{3-ethoxy-4-hydroxy-5-[(phenylsulfanyl)methyl]phenyl}prop-2-enamide
• 2-Cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamide
• 2-Propenamide, 2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-
• Brn 5634581
• ST 638 (pharmaceutical)
• St 638
• alpha-Cyano-3-ethoxy-4-hydroxy-5-(phenylthiomethyl)cinnamide

ST638

CAS: 107761-24-0

ST638 is a tyrosine kinase inhibitor that targets the JAK-STAT pathway. It inhibits the activation of STAT proteins by binding to their tyrosine kinase domain, preventing phosphorylation and consequently blocking the downstream signal. ST638 has been shown to be active against wild-type strains of bacteria, but not against mutants that have lost the gene encoding for ST638's target enzyme. Furthermore, ST638 is also an inhibitor of guanine nucleotide-binding protein (G protein), which is involved in a number of cellular processes including inflammation and exocytosis. The G protein inhibition may account for the anti-inflammatory activity observed in this drug.

Formula: C₁₉H₁₈N₂O₃S

Purity: Min. 95%

Molecular weight: 354.42 g/mol

Ref: 3D-HEA76124

ST638

CAS: 107761-24-0

ST638 is a potent inhibitor of tyrosine kinase with an IC 50 of 370 nM [1].

Formula: C₁₉H₁₈N₂O₃S

Color and Shape: Solid

Molecular weight: 354.42

Ref: TM-T21580