CAS 1078-38-2

Acetylisoniazid

Description:

Acetylisoniazid, with the CAS number 1078-38-2, is a chemical compound that is a derivative of isoniazid, which is primarily known for its use in the treatment of tuberculosis. This substance is characterized by its acetylated amine structure, which contributes to its pharmacological properties. Acetylisoniazid exhibits antibacterial activity, particularly against Mycobacterium tuberculosis, making it relevant in the context of antimicrobial therapy. It is typically administered in a pharmaceutical formulation and is known for its ability to inhibit the synthesis of mycolic acids, essential components of the bacterial cell wall. The compound is generally soluble in organic solvents and has a moderate stability profile under standard conditions. However, like many pharmaceuticals, it may have side effects and contraindications, necessitating careful consideration in clinical use. Its efficacy and safety profile are influenced by factors such as dosage, patient health status, and potential interactions with other medications. Overall, acetylisoniazid serves as an important agent in the fight against tuberculosis, contributing to the broader category of antitubercular drugs.

Formula: C₈H₉N₃O₂

InChI: InChI=1S/C8H9N3O2/c1-6(12)10-11-8(13)7-2-4-9-5-3-7/h2-5H,1H3,(H,10,12)(H,11,13)

InChI key: InChIKey=CVBGNAKQQUWBQV-UHFFFAOYSA-N

SMILES: C(NNC(C)=O)(=O)C=1C=CN=CC1

Synonyms:

• 1-Acetyl-2-isonicotinoylhydrazine
• 4-Pyridinecarboxylic acid, 2-acetylhydrazide
• Acetylisoniazid
• Acetylisoniazide
• Hydrazine, 1-acetyl-2-isonicotinoyl-
• Hydrazine,1-Acetyl-2-Isonicotinyl-
• N'-acetylpyridine-4-carbohydrazide
• N-Acetyl-N′-isonicotinoylhydrazine
• N-Acetylisoniazid
• N-Acetylisonicotinylhydrazide
• N-Monoacetylisoniazid

4-Pyridinecarboxylicacid, 2-acetylhydrazide

CAS: 1078-38-2

Formula: C₈H₉N₃O₂

Color and Shape: Solid

Molecular weight: 179.1760

Ref: IN-DA007VKT

Acetylisoniazid

CAS: 1078-38-2

Formula: C₈H₉N₃O₂

Molecular weight: 179.18

Ref: 4Z-I-424

Acetylisoniazid

CAS: 1078-38-2

Acetylisoniazid

Purity: 98%

Ref: 54-OR1037463

Acetyl Isoniazid

CAS: 1078-38-2

Formula: C₈H₉N₃O₂

Color and Shape: White To Off-White

Molecular weight: 179.18

Ref: TR-A179520

Acetylisoniazide

CAS: 1078-38-2

Acetylisoniazide is an antimicrobial agent that belongs to the group of enzyme inducers. It is a prodrug that is hydrolyzed by esterases in the body to picolinic acid and acetyl-CoA. Acetylisoniazide has been shown to inhibit the growth of bacteria, yeast, and fungi that are resistant to other antimicrobial agents. This drug also inhibits the production of pyrazinoic acid, a metabolite of tryptophan synthesis and an activator of macrophages. Acetylisoniazide has been shown to have a synergistic effect with isoniazid for the treatment of tuberculosis. The polymerase chain reaction (PCR) method was used for this study. Acetylisoniazide binds to human serum albumin, which decreases its solubility in water and affects its reactivity with fluorescence probes. The matrix effect was investigated using rat liver microsomes as a model system.

Formula: C₈H₉N₃O₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 179.18 g/mol

Ref: 3D-FA17025

Acetyl Isoniazid

CAS: 1078-38-2

Formula: C₈H₉N₃O₂

Molecular weight: 179.18

Ref: ST-EA-CP-I10007