CAS 107807-24-9

epelmycin B

Description:

Epelmycin B is a natural product belonging to the class of macrolide antibiotics, specifically derived from the fermentation of certain Streptomyces species. It exhibits a complex structure characterized by a large lactone ring, which is typical of macrolides, and contains multiple functional groups that contribute to its biological activity. Epelmycin B is known for its antimicrobial properties, particularly against a range of Gram-positive bacteria and some fungi, making it of interest in pharmaceutical applications. Its mechanism of action generally involves inhibition of protein synthesis by binding to the bacterial ribosome. The compound is also noted for its potential in cancer research due to its cytotoxic effects on certain tumor cell lines. As with many antibiotics, the development of resistance is a concern, necessitating ongoing research into its efficacy and potential modifications to enhance its therapeutic profile. Safety and toxicity profiles are critical for its use, and further studies are often required to fully understand its pharmacokinetics and pharmacodynamics.

Formula: C₄₂H₅₁NO₁₆

InChI: InChI=1/C42H51NO16/c1-8-42(51)15-25(29-30(33(42)40(50)52-7)37(49)31-32(36(29)48)35(47)28-19(34(31)46)10-9-11-21(28)44)57-26-12-20(43(5)6)38(17(3)53-26)58-27-14-23-39(18(4)54-27)59-41-24(56-23)13-22(45)16(2)55-41/h9-11,16-18,20,23-27,33,38-39,41,44,48-49,51H,8,12-15H2,1-7H3

Synonyms:

• 1-Naphthacenecarboxylic acid, 4-[[[2''',3''-anhydro]-O-3,6-dideoxy-α-L-erythro-hexopyranos-4-ulos-1-yl-(1→4)-O-2,6-dideoxy-α-L-lyxo-hexopyranosyl-(1→4)-2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7,12-tetrahydroxy-6,11-dioxo-, methyl ester
• epelmycin B
• Epelmycin B
• methyl 4-({4-(dimethylamino)-5-[(2,9-dimethyl-3-oxooctahydro-2H,5aH-dipyrano[2,3-b:4',3'-e][1,4]dioxin-7-yl)oxy]-6-methyltetrahydro-2H-pyran-2-yl}oxy)-2-ethyl-2,5,7,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate (non-preferred name)
• 1-Naphthacenecarboxylic-acid, 4-(((2''',3''-anhydro)-O-3,6-dideoxy-alpha-L-erythro-hexopyranos-4-ulosyl-(1-4)-O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-ethyl-1,2,3

Epelmycin B

CAS: 107807-24-9

Epelmycin B possesses activity against Gram-positive bacteria, Gram-negative bacteria, and Candida albicans, and also exhibits activity against leukemia L1210.

Formula: C₄₂H₅₁NO₁₆

Color and Shape: Solid

Molecular weight: 825.851

Ref: TM-TN10640