CAS 107868-30-4
:Exemestane
Description:
Exemestane is a synthetic steroidal aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It functions by irreversibly binding to the aromatase enzyme, thereby inhibiting the conversion of androgens to estrogens, which is crucial in the growth of certain breast tumors. The chemical formula of Exemestane is C20H24O2, and it has a molecular weight of approximately 296.4 g/mol. It is characterized by its structural similarity to the natural steroid testosterone, which allows it to effectively compete with and inhibit the aromatase enzyme. Exemestane is typically administered orally and is known for its relatively favorable side effect profile compared to other hormonal therapies. Common side effects may include hot flashes, fatigue, and joint pain. Its pharmacokinetics indicate that it is well-absorbed, with a half-life that supports once-daily dosing. Overall, Exemestane plays a significant role in the management of breast cancer, particularly in patients who have undergone surgery or are at high risk of recurrence.
Formula:C20H24O2
InChI:InChI=1/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14?,15?,16?,19-,20+/m1/s1
InChI key:InChIKey=BFYIZQONLCFLEV-DAELLWKTSA-N
SMILES:C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)C(=O)CC4)[H])(CC(=C)C1=CC(=O)C=C2)[H])[H]
Synonyms:- (8Ξ,9Ξ,14Ξ)-6-Methylideneandrosta-1,4-Diene-3,17-Dione
- 10,13-Dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-
- 6-Methylenandrosta-1,4-diene-3,17-dione
- 6-Methyleneandrosta-1,4-diene-3,17-dione
- 6-Methylideneandrosta-1,4-Diene-3,17-Dione
- Androsta-1,4-diene-3,17-dione, 6-methylene-
- Aromasil
- Aromasin
- Exemestan
- Exemestane(Aromasin)
- Exemestone
- Fce 24304
- Exemestane
- (8ξ,9ξ,14ξ)-6-methylideneandrosta-1,4-diene-3,17-dione
- 6-Methyleneandrosta-1,4-diene-3,17-dione, FCE-24304, Aromasin
- Exemestance
- See more synonyms
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Found 19 products.
EXEMESTANE CRS
CAS:<p>EXEMESTANE CRS</p>Formula:C20H24O2Color and Shape:AddedMolecular weight:296.4034EXEMESTANE FOR SYSTEM SUITABILITY CRS
CAS:<p>EXEMESTANE FOR SYSTEM SUITABILITY CRS</p>Formula:C20H24O2Color and Shape:White. Slightly Yellow. Powder., White. Slightly Yellow. Powder.Molecular weight:296.4034Exemestane
CAS:<p>Adrenal cortical hormones and their derivatives nesoi</p>Formula:C20H24O2Color and Shape:White Light Yellow Light Brown PowderMolecular weight:296.17763Exemestane
CAS:Formula:C20H24O2Purity:98.0 - 102.0 % (dried basis)Color and Shape:White or almost white crystalline powderMolecular weight:296.401,4-Androstadien-3,17-dione-6-methylene-16,16-d2
CAS:Purity:98 atom % DColor and Shape:White SolidMolecular weight:298.42Exemestane
CAS:Controlled Product<p>Applications Exemestane is an antineoplastic (hormonal).<br>References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)<br></p>Formula:C20H24O2Color and Shape:White To Light GreenMolecular weight:296.40Exemestane-19-d3
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications An antineoplastic (hormonal).<br>References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)<br></p>Formula:C20H21D3O2Color and Shape:NeatMolecular weight:299.42Exemestane
CAS:Controlled Product<p>Exemestane is a drug that belongs to the class of chemical inhibitors. It binds to the aromatase enzyme, which is necessary for estrogen production in postmenopausal women. This leads to a reduction in estrogen levels and can be used for the treatment of breast cancer. Exemestane has been shown to have inhibitory properties on cell signaling pathways, such as by reducing the cytosolic Ca2+ concentration and inhibiting protein synthesis in cells. The drug also has metabolic effects, including an increase in cholesterol levels.</p>Formula:C20H24O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:296.4 g/molExemestane-13C,D3
CAS:Controlled Product<p>Applications Exemestane-13C,D3 is the labeled analogue of Exemestane (E957000), an antineoplastic (hormonal).<br>References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)<br></p>Formula:C1913CH21D3O2Color and Shape:NeatMolecular weight:300.416-Methylidene-3-oxoandrosta-1,4-dien-17β-yl Formate
CAS:Controlled Product<p>Applications 6-Methylidene-3-oxoandrosta-1,4-dien-17β-yl Formate is Exemestane impurity I. Exemestane(E957000) is an antineoplastic (hormonal).<br>References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)<br></p>Formula:C21H26O3Color and Shape:NeatMolecular weight:326.429(8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methylene-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17(10H,14H)-dione
CAS:Formula:C20H24O2Purity:99%Color and Shape:SolidMolecular weight:296.4034Exemestane
CAS:<p>Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.</p>Formula:C20H24O2Purity:99.35% - 99.35%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:296.4
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