Dendrotoxin I is a neurotoxic peptide derived from the venom of certain species of mamba snakes, particularly the black mamba (Dendroaspis polylepis). It is classified as a small protein, consisting of approximately 60 amino acids, and is known for its potent effects on the nervous system. Dendrotoxin I primarily functions as a blocker of voltage-gated potassium channels, which leads to prolonged depolarization of neurons and increased neurotransmitter release. This mechanism can result in heightened excitability of nerve cells, contributing to the neurotoxic effects observed in envenomation. The substance has been studied for its potential applications in neuroscience research, particularly in understanding ion channel function and neuronal signaling. Additionally, its unique structure and activity make it a subject of interest for drug development and therapeutic applications. However, due to its toxicity, handling Dendrotoxin I requires caution and appropriate safety measures in laboratory settings.

DENDROTOXIN I

107950-33-4: Dendrotoxin I is a neurotoxic peptide derived from the venom of certain species of mamba snakes, particularly the black mamba (Dendroaspis polylepis). It is classified as a small protein, consisting of approximately 60 amino acids, and is known for its potent effects on the nervous system. Dendrotoxin I primarily functions as a blocker of voltage-gated potassium channels, which leads to prolonged depolarization of neurons and increased neurotransmitter release. This mechanism can result in heightened excitability of nerve cells, contributing to the neurotoxic effects observed in envenomation. The substance has been studied for its potential applications in neuroscience research, particularly in understanding ion channel function and neuronal signaling. Additionally, its unique structure and activity make it a subject of interest for drug development and therapeutic applications. However, due to its toxicity, handling Dendrotoxin I requires caution and appropriate safety measures in laboratory settings.

Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 and

Dendrotoxin-I

<p>Dendrotoxin I is a synthetic black mamba snake toxin sourced from the block mamba, Dendroaspis polylepis polylepis and is a voltage-dependent K+ channel blocker. This product has disulfide bonds between Cys7-Cys57, Cys16-Cys40, and Cys32-Cys53 and is available as a 0.1mg vial.</p>

CAS 107950-33-4

DENDROTOXIN I

Dendrotoxin-I

Ref: TM-T80064

Dendrotoxin I

Ref: 3D-PDN-4330-S