CAS 108027-45-8
:Cyclosporin U (9CI)
Description:
Cyclosporin U, also known by its CAS number 108027-45-8, is a cyclic polypeptide that belongs to the class of immunosuppressive agents. It is derived from the fungus Tolypocladium inflatum and is structurally related to cyclosporin A, though it exhibits distinct pharmacological properties. Cyclosporin U is characterized by its ability to inhibit T-cell activation and proliferation, making it valuable in preventing organ transplant rejection and treating autoimmune diseases. The compound functions by binding to cyclophilin, which subsequently inhibits calcineurin, a critical enzyme in T-cell signaling pathways. This action leads to a reduction in the production of interleukin-2 and other cytokines, thereby modulating the immune response. In terms of solubility, cyclosporin U is typically lipophilic, which influences its absorption and distribution in biological systems. Its therapeutic applications are accompanied by potential side effects, including nephrotoxicity and increased susceptibility to infections, necessitating careful monitoring during treatment. Overall, cyclosporin U represents a significant advancement in immunosuppressive therapy, with ongoing research exploring its full potential and mechanisms of action.
Formula:C61H109N11O12
Synonyms:- CyclosporinA, 11-L-leucine-
- 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane,cyclic peptide deriv.
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-L-leucyl]
- CYCLOSPORINE RESOLUTION MIXTURE (25 MG)
- Cyclosporine Impurity 11
- Cyclosporin Impurity 11(Cyclosporin U)
- Cyclosporine Resolution Mixture
- Cyclosporin U (9CI)
- Cyclosporin A, 11-L-leucine-
- Cyclosporin Impurity U
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Found 3 products.
Cyclosporine U
CAS:<p>Cyclosporine U is a cyclic polypeptide immunosuppressant, which is a derivative of the natural product Cyclosporine A, produced by the fermentation process involving the filamentous fungus *Tolypocladium inflatum*. It primarily acts by inhibiting the activity of calcineurin, a phosphatase enzyme, which in turn blocks the transcription of interleukin-2 and other cytokines. This mechanism suppresses the activation of T-lymphocytes, a crucial component in the immune response.</p>Formula:C61H109N11O12Purity:Min. 95%Molecular weight:1,188.58 g/mol
