CAS 108068-98-0

KT 5720

Description:

KT 5720 is a selective inhibitor of protein kinase A (PKA), which plays a crucial role in various cellular processes, including metabolism, gene expression, and cell proliferation. This compound is characterized by its ability to modulate signaling pathways by specifically targeting the PKA enzyme, thereby influencing downstream effects in cellular signaling. KT 5720 is often utilized in research to study the role of PKA in various biological contexts, including cancer and cardiovascular diseases. The compound is typically administered in vitro and in vivo to assess its effects on cellular functions and to explore potential therapeutic applications. Its chemical structure includes a quinazoline core, which is common among kinase inhibitors, contributing to its binding affinity and specificity. KT 5720 is known for its relatively low toxicity profile, making it a valuable tool in pharmacological studies. As with many research chemicals, proper handling and safety protocols should be observed when working with KT 5720 in laboratory settings.

Formula: C₃₂H₃₁N₃O₅

InChI: InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1

InChI key: InChIKey=ZHEHVZXPFVXKEY-RUAOOFDTSA-N

SMILES: C[C@@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@@](O1)(C[C@]2(C(OCCCCCC)=O)O)[H])=CC=CC8

Synonyms:

• 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo (3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9alpha,10beta,12alpha)-
• 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10R,12S)-rel-
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-
• Antibiotic KT 5720
• Kt 5720
• hexyl (5R,6S,8S)-6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate
• hexyl 6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate

KT5720

CAS: 108068-98-0

KT5720

Formula: C₃₂H₃₁N₃O₅

Purity: By hplc: 98.87% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 537.61g/mol

Ref: 54-BIK1003

KT 5720

CAS: 108068-98-0

Formula: C₃₂H₃₁N₃O₅

Purity: ≥ 95.0%

Color and Shape: White powder or solid

Molecular weight: 537.61

Ref: 7W-GK5661

KT5720

CAS: 108068-98-0

KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).

Formula: C₃₂H₃₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 537.61

Ref: TM-T15669

KT 5720

Controlled Product

CAS: 108068-98-0

Formula: C₃₂H₃₁N₃O₅

Color and Shape: Neat

Molecular weight: 537.606

Ref: TR-K660353

KT5720

CAS: 108068-98-0

KT5720 is a selective protein kinase A (PKA) inhibitor, which is a synthetic chemical compound often utilized in laboratory research. The source of this compound stems from chemical synthesis processes used to investigate intracellular signaling pathways. Its mode of action involves competitive inhibition, where it binds to the ATP-binding site on the PKA enzyme, thereby obstructing the enzyme's activity and preventing the phosphorylation of target substrates.

Formula: C₃₂H₃₁N₃O₅

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 537.61 g/mol

Ref: 3D-BK162735