CAS 108322-12-9

thymidine 5'-diphosphate sodium

Description:

Thymidine 5'-diphosphate sodium, commonly referred to as dTDP, is a nucleotide that plays a crucial role in various biochemical processes, particularly in DNA synthesis and metabolism. It is a derivative of thymidine, consisting of a thymine base, a deoxyribose sugar, and two phosphate groups. The sodium salt form enhances its solubility in aqueous solutions, making it suitable for laboratory applications. dTDP is involved in the synthesis of deoxythymidine triphosphate (dTTP), which is essential for DNA replication and repair. Its structure allows it to participate in enzymatic reactions, particularly those catalyzed by nucleotidyltransferases. In addition to its biological significance, dTDP can be utilized in various biochemical assays and research applications, including studies on nucleotide metabolism and enzyme kinetics. The compound is typically stable under physiological conditions but may be sensitive to extreme pH levels or prolonged exposure to light. Overall, thymidine 5'-diphosphate sodium is a vital component in molecular biology and biochemistry.

Formula: C₁₀H₁₃N₂O₁₁P₂

InChI: InChI=1/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1

Synonyms:

• Thymidine-3,5-diphosphate, Disodium Salt
• trisodium 5'-O-[(phosphonatooxy)phosphinato]thymidine

Thymidine 5'-diphosphate xsodium salt

CAS: 108322-12-9

Formula: C₁₀H₁₅N₂NaO₁₁P₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 424.1702

Ref: IN-DA0083OT

Thymidine 5''-diphosphate sodium salt

CAS: 108322-12-9

Formula: C₁₀H₁₆N₂O₁₁P₂·xNa

Molecular weight: 402.19 (free acid b

Ref: 7W-GK6758

Thymidine 5’-Diphosphate Sodium Salt (~90%)

CAS: 108322-12-9

Stability Hygroscopic
Applications Thymidine 5’-Diphosphate Sodium Salt is a nucleoside diphosphate derived from phosphorylation of Thymidine (T412000). It is produced from Thymidine monophosphate by Thymidylate kinase (TMPK), a nucleoside monophosphate kinase and can be futher phosphorylated to its active triphosphate antiviral or antitumor moieties. A proximate precursor for DNA synthesis.
References Baumann, E.A. et al.: Biochim. Biphys. Acta Nucleic Acid Protein Synth., 565, 107 (1979); Kohler, J.J. et al.: Lab. Invest., 90, 383 (2010);

Formula: C₁₀H₁₅N₂O₁₁P₂·Na

Purity: ~90%

Color and Shape: Neat

Molecular weight: 424.17

Ref: TR-T412010