CAS 108383-95-5

naltiazem

Description:

Naltiazem, with the CAS number 108383-95-5, is a pharmaceutical compound primarily classified as a calcium channel blocker. It is structurally related to other benzothiazepine derivatives and is utilized in the treatment of cardiovascular conditions, particularly hypertension and angina pectoris. The mechanism of action involves the inhibition of calcium ions from entering cardiac and smooth muscle cells, leading to vasodilation and reduced myocardial oxygen demand. Naltiazem exhibits a moderate lipophilicity, which influences its absorption and distribution in the body. It is typically administered orally and undergoes hepatic metabolism, with its pharmacokinetics characterized by a relatively long half-life. Common side effects may include dizziness, headache, and peripheral edema, reflecting its impact on vascular smooth muscle. As with other calcium channel blockers, caution is advised in patients with certain pre-existing conditions, such as heart failure or significant hypotension. Overall, naltiazem represents a valuable therapeutic option in managing specific cardiovascular disorders.

Formula: C₂₆H₂₈N₂O₄S

InChI: InChI=1/C26H28N2O4S/c1-17(29)32-23-24(19-9-12-20(31-4)13-10-19)33-25-21-8-6-5-7-18(21)11-14-22(25)28(26(23)30)16-15-27(2)3/h5-14,23-24H,15-16H2,1-4H3/t23-,24+/m1/s1

Synonyms:

• (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate
• Naltiazem
• 3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-(2-(dimethylamino)ethyl)naphtho(1,2-b)1,4-thiazepin-4(5H)-one
• Naphtho(1,2-b)(1,4)thiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, cis-(+)-

Naltiazem

CAS: 108383-95-5

Naltiazem, a calcium channel antagonist, is used potentially for the treatment of arrhythmias, hypertension and myocardial infarction.

Formula: C₂₆H₂₈N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 464.58

Ref: TM-T28130