CAS 1086062-66-9

Omipalisib

Description:

Omipalisib, also known by its chemical name GSK2126458, is a small molecule inhibitor primarily targeting the phosphoinositide 3-kinase (PI3K) pathway, which plays a crucial role in various cellular processes, including growth, proliferation, and survival. It is particularly noted for its potential therapeutic applications in oncology, especially in cancers with aberrant PI3K signaling. Omipalisib exhibits a high degree of selectivity for specific PI3K isoforms, which contributes to its efficacy and safety profile. The compound is typically administered orally and has been evaluated in clinical trials for its effectiveness in treating solid tumors and hematological malignancies. Its mechanism of action involves the inhibition of downstream signaling pathways that are activated by PI3K, thereby inducing apoptosis in cancer cells. Additionally, Omipalisib's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are critical for determining its dosing regimen and potential drug interactions. Overall, Omipalisib represents a significant advancement in targeted cancer therapy, focusing on the modulation of key signaling pathways involved in tumorigenesis.

Formula: C₂₅H₁₇F₂N₅O₃S

InChI: InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3

InChI key: InChIKey=CGBJSGAELGCMKE-UHFFFAOYSA-N

SMILES: N(S(=O)(=O)C1=C(F)C=C(F)C=C1)C2=CC(C3=CC=4C(=CC=NC4C=C3)C=5C=CN=NC5)=CN=C2OC

Synonyms:

• 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
• Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
• Gsk 2126458
• Gsk 458
• Gsk2126458
• Omipalisib

GSK-2126458

CAS: 1086062-66-9

Formula: C₂₅H₁₇F₂N₅O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 505.4960

Ref: IN-DA008TGQ

2,4-Difluoro-N-(2-Methoxy-5-(4-(Pyridazin-4-Yl)Quinolin-6-Yl)Pyridin-3-Yl)Benzenesulfonamide

CAS: 1086062-66-9

2,4-Difluoro-N-(2-Methoxy-5-(4-(Pyridazin-4-Yl)Quinolin-6-Yl)Pyridin-3-Yl)Benzenesulfonamide

Purity: 98%

Molecular weight: 505.5g/mol

Ref: 54-PC108754

Omipalisib

CAS: 1086062-66-9

Omipalisib

Purity: ≥98%

Molecular weight: 505.5g/mol

Ref: 54-BUP06065

GSK2126458

CAS: 1086062-66-9

Ref: 7W-GW9665

Omipalisib

CAS: 1086062-66-9

Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.

Formula: C₂₅H₁₇F₂N₅O₃S

Purity: 98% - 99.8%

Color and Shape: Solid

Molecular weight: 505.5

Ref: TM-T1861

GSK 2126458

Controlled Product

CAS: 1086062-66-9

Formula: C₂₅H₁₇F₂N₅O₃S

Color and Shape: Neat

Molecular weight: 505.5

Ref: TR-G797500

GSK 2126458

CAS: 1086062-66-9

PI3K enzyme inhibitor; antineoplastic

Purity: Min. 98 Area-%

Color and Shape: Powder

Ref: 3D-FD43337