CAS 108612-45-9

Mizolastine

Description:

Mizolastine is an antihistamine medication primarily used to treat allergic conditions such as rhinitis and urticaria. It functions as a selective antagonist of the H1 histamine receptor, effectively alleviating symptoms associated with allergic reactions. Mizolastine is characterized by its relatively long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits a low potential for sedation compared to first-generation antihistamines, making it suitable for individuals who need to avoid drowsiness. Chemically, Mizolastine is classified as a piperidine derivative and possesses a unique structure that contributes to its pharmacological properties. It is typically administered orally and is well-absorbed in the gastrointestinal tract. The substance is also noted for its anti-inflammatory effects, which may provide additional therapeutic benefits in managing allergic responses. As with any medication, potential side effects may include headache, dry mouth, and gastrointestinal disturbances, though these are generally mild. Overall, Mizolastine represents a valuable option in the management of allergic symptoms with a favorable safety profile.

Formula: C₂₄H₂₅FN₆O

InChI: InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)

InChI key: InChIKey=PVLJETXTTWAYEW-UHFFFAOYSA-N

SMILES: C(N1C(=NC=2C1=CC=CC2)N3CCC(N(C)C=4NC(=O)C=CN4)CC3)C5=CC=C(F)C=C5

Synonyms:

• 2-[[1-[1-[(4-Fluorophenyl)Methyl]Benzoimidazol-2-Yl]-4-Piperidyl]-Methyl-Amino]-3H-Pyrimidin-4-One
• 2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone
• 2-[[1-[1-[(4-Fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1H-pyrimidin-6-one
• 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(1H)-pyrimidinone
• 2-[{1-[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]piperidin-4-yl}(methyl)amino]pyrimidin-4(3H)-one
• 4(1H)-Pyrimidinone, 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-
• 4(1H)-Pyrimidinone,2-((1-(1-((4-Fluorophenyl)Methyl)-1H-Benzimidazol-2-Yl)-4-P
• 4(3H)-Pyrimidinone, 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-
• Iperidinyl)Methylamino)-
• Mistamine
• Mizolastine HCl
• Mizollen
• Mkc 431
• Sl 850324
• Zolistan

Mizolastine

CAS: 108612-45-9

Mizolastine (SL 850324), an antihistamine with IC50 of 47 nM, treats allergies like hay fever and hives.

Formula: C₂₄H₂₅FN₆O

Purity: 98% - 99.75%

Color and Shape: Solid

Molecular weight: 432.49

Ref: TM-T0118

Mizolastine

CAS: 108612-45-9

Mizolastine

Purity: ≥98%

Molecular weight: 432.49g/mol

Ref: 54-BUP15036

Mizolastine

CAS: 108612-45-9

Formula: C₂₄H₂₅FN₆O

Color and Shape: White To Off-White Solid

Molecular weight: 432.50

Ref: 4Z-M-191001

Mizolastine-13C-d3

CAS: 108612-45-9

Formula: C₂₃₁₃CH₂₂D₃FN₆O

Color and Shape: White To Off-White Solid

Molecular weight: 436.51

Ref: 4Z-M-191002

Mizolastine

CAS: 108612-45-9

Mizolastine

Formula: C₂₄H₂₅FN₆O

Purity: 98%

Color and Shape: solid

Molecular weight: 432.50g/mol

Ref: 54-PC901122

Mizolastine

CAS: 108612-45-9

Formula: C₂₄H₂₅FN₆O

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 432.50

Ref: 3B-M2756

Mizolastine

CAS: 108612-45-9

Applications A highly selective histamine H1-receptor antagonist (with no anticholinergic, antiadrenergic, or antiserotonin activity) for use in the treatment of allergic disorders, especially rhinitis and urticaria.
References Simons, F.E.R.: Clin. Alp. Allergy, 29, 3 (1999); Brostoff, J. et al.: Allergy, 51, 251 (1996); Gensthaler, B.M.: Pharm. Zeit., 143, 228 (1998);

Formula: C₂₄H₂₅FN₆O

Color and Shape: Neat

Molecular weight: 432.49

Ref: TR-M385400

Mizolastine-d3

Controlled Product

CAS: 108612-45-9

Formula: C₂₄H₂₂D₃FN₆O

Color and Shape: Neat

Molecular weight: 435.51

Ref: TR-M385402

Mizolastine-13C,d3

Controlled Product

CAS: 108612-45-9

Formula: CC₂₃D₃H₂₂FN₆O

Color and Shape: Neat

Molecular weight: 436.504

Ref: TR-M385403