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CAS 108731-95-9

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Ramipril-diketopiperazine

Description:
Ramipril-diketopiperazine, identified by the CAS number 108731-95-9, is a derivative of the angiotensin-converting enzyme (ACE) inhibitor ramipril, which is primarily used in the treatment of hypertension and heart failure. This compound features a diketopiperazine structure, which is a cyclic dipeptide that can influence its pharmacological properties. The characteristics of Ramipril-diketopiperazine include its ability to inhibit the ACE enzyme, thereby reducing the production of angiotensin II, a potent vasoconstrictor. This action leads to vasodilation, decreased blood pressure, and reduced workload on the heart. The diketopiperazine moiety may enhance the compound's stability and bioavailability compared to its parent compound. Additionally, the compound may exhibit specific interactions with biological targets, influencing its efficacy and safety profile. As with many pharmaceutical compounds, the solubility, permeability, and metabolic stability are critical factors that determine its therapeutic potential and application in clinical settings.
Formula:C23H30N2O4
InChI:InChI=1S/C23H30N2O4/c1-3-29-23(28)19(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-18-11-7-10-17(18)14-20(25)22(24)27/h4-6,8-9,15,17-20H,3,7,10-14H2,1-2H3/t15-,17-,18-,19-,20-/m0/s1
InChI key:InChIKey=KOVMAAYRBJCASY-JBDAPHQKSA-N
SMILES:O=C1N2[C@](C(=O)N([C@@H](CCC3=CC=CC=C3)C(OCC)=O)[C@H]1C)(C[C@]4([C@@]2(CCC4)[H])[H])[H]
Synonyms:
  • 2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic acid, decahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-, ethyl ester, (αS,3S,5aS,8aS,9aS)-
  • 2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic acid, decahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-, ethyl ester, [3S-[2(R*),3α,5aβ,8aβ,9aβ]]-
  • [3S-[2(R*),3a,5a,8a,9a]]-Decahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic Acid Ethyl Ester
  • [3S-[2(R*),3a,5ab,8ab,9ab]]-Decahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic Acid Ethyl Ester
  • Ramipril-diketopiperazine
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