CAS 108731-95-9: Ramipril-diketopiperazine

Description: Ramipril-diketopiperazine, identified by the CAS number 108731-95-9, is a derivative of the angiotensin-converting enzyme (ACE) inhibitor ramipril, which is primarily used in the treatment of hypertension and heart failure. This compound features a diketopiperazine structure, which is a cyclic dipeptide that can influence its pharmacological properties. The characteristics of Ramipril-diketopiperazine include its ability to inhibit the ACE enzyme, thereby reducing the production of angiotensin II, a potent vasoconstrictor. This action leads to vasodilation, decreased blood pressure, and reduced workload on the heart. The diketopiperazine moiety may enhance the compound's stability and bioavailability compared to its parent compound. Additionally, the compound may exhibit specific interactions with biological targets, influencing its efficacy and safety profile. As with many pharmaceutical compounds, the solubility, permeability, and metabolic stability are critical factors that determine its therapeutic potential and application in clinical settings.

Formula: C₂₃H₃₀N₂O₄

InChI: InChI=1S/C23H30N2O4/c1-3-29-23(28)19(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-18-11-7-10-17(18)14-20(25)22(24)27/h4-6,8-9,15,17-20H,3,7,10-14H2,1-2H3/t15-,17-,18-,19-,20-/m0/s1

InChI key: InChIKey=KOVMAAYRBJCASY-JBDAPHQKSA-N

SMILES: O=C(OCC)C(N1C(=O)C2N(C(=O)C1C)C3CCCC3C2)CCC=4C=CC=CC4

Synonyms:

• 2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic acid, decahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-, ethyl ester, (αS,3S,5aS,8aS,9aS)-
• 2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic acid, decahydro-3-methyl-1,4-dioxo-α-(2-phenylethyl)-, ethyl ester, [3S-[2(R*),3α,5aβ,8aβ,9aβ]]-
• [3S-[2(R*),3a,5a,8a,9a]]-Decahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic Acid Ethyl Ester
• [3S-[2(R*),3a,5ab,8ab,9ab]]-Decahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic Acid Ethyl Ester
• Ramipril-diketopiperazine

Ramipril impurity D CRS

CAS: 108731-95-9

• Formula: C₂₃H₃₀N₂O₄
• Molecular weight: 398.4953

Ramipril Related Compound D (Ethyl (S)-2-[(3S,5aS,8aS,9aS)-3-methyl-1,4-dioxodecahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl]-4-phenylbutanoate)

CAS: 108731-95-9

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

• Formula: C₂₃H₃₀N₂O₄
• Color and Shape: White Powder
• Molecular weight: 398.22056

Ramipril EP Impurity D (Ramipril USP Related Compound D, Ramipril Diketopiperazine)

CAS: 108731-95-9

• Formula: C₂₃H₃₀N₂O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 398.50

Ethyl (2S)-2-[(3S,5aS,8aS,9aS)-3-Methyl-1,4-dioxodecahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl]-4-phenylbutanoate (Ramipril Diketopiperazine)

CAS: 108731-95-9

• Formula: C₂₃H₃₀N₂O₄
• Color and Shape: Neat
• Molecular weight: 398.50

Ramipril Diketopiperazine

CAS: 108731-95-9

Impurity Ramipril EP Impurity D Stability Hygroscopic Applications Ramipril Diketopiperazine (Ramipril EP Impurity D) is …

• Formula: C₂₃H₃₀N₂O₄
• Color and Shape: White
• Molecular weight: 398.50

Ramipril diketopiperazine

CAS: 108731-95-9

Ramipril diketopiperazine is a pharmaceutical preparation that is available in the form of particles. It …

• Formula: C₂₃H₃₀N₂O₄
• Purity: Min. 95%
• Molecular weight: 398.5 g/mol