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CAS 108736-10-3

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Ramiprilat Diketopiperazine

Description:
Ramiprilat Diketopiperazine, with the CAS number 108736-10-3, is a pharmacologically active compound derived from ramipril, an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension and heart failure. This substance features a diketopiperazine structure, which is characterized by a cyclic dipeptide framework that contributes to its biological activity. Ramiprilat itself is the active metabolite of ramipril, exhibiting potent antihypertensive effects by inhibiting the conversion of angiotensin I to angiotensin II, a peptide that causes blood vessels to constrict. The diketopiperazine moiety may enhance the compound's stability and bioavailability. In terms of solubility, it is typically soluble in polar solvents, which is important for its pharmacokinetic properties. The compound's safety profile and efficacy are well-studied, making it a significant focus in cardiovascular pharmacotherapy. As with any pharmaceutical agent, its use should be guided by clinical considerations and potential interactions with other medications.
Formula:C21H21D5N2O4
InChI:InChI=1/C21H26N2O4/c1-13-19(24)23-16-9-5-8-15(16)12-18(23)20(25)22(13)17(21(26)27)11-10-14-6-3-2-4-7-14/h2-4,6-7,13,15-18H,5,8-12H2,1H3,(H,26,27)/t13-,15-,16-,17+,18-/m0/s1/i2D,3D,4D,6D,7D
Synonyms:
  • [3S-[2(R*),3a,5ab,8ab,9ab]]-Decahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic Acid
  • [3S-[2(R*),3a,5a,8a,9a]]-Decahydro-3-methyl-1,4-dioxo-a-(2-phenylethyl)-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazine-2-acetic Acid
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