CAS 108736-35-2

lanreotide

Description:

Lanreotide is a synthetic octapeptide analog of somatostatin, a naturally occurring hormone that inhibits the secretion of several other hormones. It is primarily used in the treatment of acromegaly, a condition characterized by excessive growth hormone production, and for managing certain neuroendocrine tumors. Lanreotide functions by binding to somatostatin receptors, leading to a decrease in growth hormone and insulin-like growth factor 1 (IGF-1) levels. The substance is typically administered via subcutaneous injection and has a prolonged half-life, allowing for less frequent dosing compared to other treatments. Lanreotide is known for its stability and solubility in aqueous solutions, which facilitates its use in clinical settings. Common side effects may include gastrointestinal disturbances, such as diarrhea and abdominal pain, as well as potential impacts on glucose metabolism. Overall, lanreotide represents an important therapeutic option in the management of specific endocrine disorders, demonstrating the significance of peptide-based drugs in modern medicine.

Formula: C₅₄H₆₉N₁₁O₁₀S₂

InChI: InChI=1/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)

SMILES: CC(C)C1C(=NC(CSSCC(C(=NC(Cc2ccc(cc2)O)C(=NC(Cc2c[nH]c3ccccc23)C(=NC(CCCCN)C(=N1)O)O)O)O)N=C(C(Cc1ccc2ccccc2c1)N)O)C(=NC(C(C)O)C(=N)O)O)O

Synonyms:

• B-naphthyl-D-ala-cys-tyr-D-trp*lys-val-cys-thr am
• 10-(4-aminobutyl)-N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-16-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-19-{[3-(naphthalen-2-yl)alanyl]amino}-6,9,12,15,18-pentaoxo-7-(propan-2-yl)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate (1:1)
• 10-(4-aminobutyl)-N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-16-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-19-{[3-(naphthalen-2-yl)alanyl]amino}-6,9,12,15,18-pentaoxo-7-(propan-2-yl)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
• Laromustine

Lanreotide

CAS: 108736-35-2

Lanreotide, a cyclic somatostatin agonist shows a high binding affinity for the somatostatin receptor (SSTR) subtype 2 and has a 10-fold less affinity for receptor subtype 5. It is also a potent inhibitor of growth hormone secretion from pituitary cells. Furthermore, the octapeptide exhibits a direct antiproliferative effect in vivo and in vitro on the growth of cells or solid tumors from a human small cell lung carcinoma. CAS Number (lanreotide acetate): 127984-74-1.

Formula: C₅₄H₆₉N₁₁O₁₀S₂

Purity: 99.4%

Color and Shape: White

Molecular weight: 1096.34

Ref: 01-4067760

L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2→7)-disulfide

CAS: 108736-35-2

Formula: C₅₄H₆₉N₁₁O₁₀S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 1096.3234

Ref: IN-DA0039LA

Lanreotide Ditrifluoroacetate

CAS: 108736-35-2

Formula: C₅₄H₆₉N₁₁O₁₀S₂·2C₂HF₃O₂

Molecular weight: 1096.33 2*114.02

Ref: 4Z-PL-133001

Lanreotide-d8 Ditrifluoroacetate

CAS: 108736-35-2

Formula: C₅₄H₆₁D₈N₁₁O₁₀S₂·2C₂HF₃O₂

Molecular weight: 1104.38 2*114.02

Ref: 4Z-PL-133002

Lanreotide

CAS: 108736-35-2

Lanreotide, a somatostatin analogue, suppresses GH/IGF-I hypersecretion in acromegaly patients. It also used to manage neuroendocrine tumours.

Formula: C₅₄H₆₉N₁₁O₁₀S₂

Color and Shape: Solid

Molecular weight: 1096.32

Ref: TM-T20534

Lanreotide

CAS: 108736-35-2

Lanreotide

Color and Shape: Solid

Molecular weight: 1,096.32g/mol

Ref: 54-BITH3031