CAS 108852-90-0

Nemorubicin

Description:

Nemorubicin is an anthracycline antibiotic that is primarily used in cancer treatment, particularly for its antitumor properties. It is derived from the natural product daunorubicin and is known for its ability to intercalate DNA, thereby inhibiting DNA and RNA synthesis, which ultimately leads to cell death. The chemical structure of nemorubicin includes a tetracyclic ring system characteristic of anthracyclines, which contributes to its biological activity. It exhibits a broad spectrum of activity against various types of cancer, including leukemia and solid tumors. The compound is also noted for its potential cardiotoxicity, a common side effect associated with anthracycline derivatives, necessitating careful monitoring during treatment. Additionally, nemorubicin has been studied for its pharmacokinetics, which involve its absorption, distribution, metabolism, and excretion in the body. Research continues to explore its efficacy and safety profile, as well as potential combinations with other therapeutic agents to enhance its anticancer effects while minimizing adverse reactions.

Formula: C₃₂H₃₇NO₁₃

InChI: InChI=1S/C32H37NO13/c1-14-27(36)17(33-7-8-44-22(12-33)43-3)9-21(45-14)46-19-11-32(41,20(35)13-34)10-16-24(19)31(40)26-25(29(16)38)28(37)15-5-4-6-18(42-2)23(15)30(26)39/h4-6,14,17,19,21-22,27,34,36,38,40-41H,7-13H2,1-3H3/t14-,17-,19-,21-,22-,27+,32-/m0/s1

InChI key: InChIKey=CTMCWCONSULRHO-UHQPFXKFSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@@H]([C@H](O)[C@H](C)O3)N4C[C@@H](OC)OCC4)C[C@@](C(CO)=O)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6

Synonyms:

• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-[(2S)-2-methoxymorpholin-4-yl]-alpha-L-lyxo-hexopyranoside
• (1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 2,3,6-trideoxy-3-[(S)-2-methoxymorpholino]-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranoside
• (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-2,3,6-trideoxy-3-(2S)-2-methoxy-4-morpholinyl-.alpha.-L-lyxo-hexopyranosyloxy-, (8S,10S)-
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(2-methoxy-4-morpholinyl)-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-, [8S-[8α,10α(R*)]]-
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-, (8S,10S)-
• DMM Dox
• Fce 23762
• Methoxy-Morpholynil-Doxorubicin
• Methoxymorpholinyldoxorubicin
• Mmrdx
• Pnu 152243
• (8S,10S)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-

Nemorubicin

CAS: 108852-90-0

Formula: C₃₂H₃₇NO₁₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 643.6351

Ref: IN-DA008TIJ

Nemorubicin

CAS: 108852-90-0

Nemorubicin

Purity: ≥95%

Molecular weight: 643.64g/mol

Ref: 54-BUP01828

Nemorubicin

CAS: 108852-90-0

Nemorubicin (PNU 152243) is a unique doxorubicin variant with varied antitumor action, metabolism, and toxicity, effective against resistant tumors.

Formula: C₃₂H₃₇NO₁₃

Purity: 97.4%

Color and Shape: Solid

Molecular weight: 643.64

Ref: TM-T4469

Nemorubicin

CAS: 108852-90-0

Nemorubicin is an investigational chemotherapeutic agent, which is a derivative of the naturally occurring anthracycline antibiotic, doxorubicin, sourced from the bacterium Streptomyces peucetius. This compound has been modified to enhance its therapeutic profile. Its mode of action involves the inhibition of topoisomerase II, an essential enzyme for DNA replication and repair, leading to DNA damage and apoptosis in rapidly dividing cancer cells.

Formula: C₃₂H₃₇NO₁₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 643.64 g/mol

Ref: 3D-BN180615