CAS 108885-68-3
:Taccalonolide A
Description:
Taccalonolide A is a natural compound classified as a diterpenoid, primarily derived from the plant Tacca palmata. It is known for its unique structure, which features a complex arrangement of rings and functional groups, contributing to its biological activity. Taccalonolide A exhibits significant cytotoxic properties, making it a subject of interest in cancer research, particularly for its potential as a chemotherapeutic agent. The compound functions by disrupting microtubule dynamics, similar to other well-known anticancer drugs, but with a distinct mechanism that may overcome resistance seen with traditional therapies. Additionally, Taccalonolide A has been studied for its effects on various cancer cell lines, demonstrating promising results in inhibiting cell proliferation. Its solubility and stability in biological systems are important factors for its therapeutic application. Overall, Taccalonolide A represents a fascinating area of study in medicinal chemistry, with ongoing research aimed at understanding its full potential and optimizing its use in cancer treatment.
Formula:C36H46O14
InChI:InChI=1S/C36H46O14/c1-12-10-19-35(8,36(9,44)32(43)50-19)24-21(12)34(7)22(28(24)45-13(2)37)20-23(29(46-14(3)38)31(34)48-16(5)40)33(6)17(25(41)26(20)42)11-18-27(49-18)30(33)47-15(4)39/h10,12,17-18,20-24,26-31,42,44H,11H2,1-9H3/t12-,17-,18+,20+,21+,22-,23-,24+,26-,27+,28-,29+,30+,31+,33+,34-,35+,36-/m1/s1
InChI key:InChIKey=PTTJLTMUKRRHAT-VJAKQJMOSA-N
SMILES:C[C@@]12[C@]([C@]3([C@]([C@H](OC(C)=O)[C@@H]1OC(C)=O)([C@@]4(C)[C@@H](OC(C)=O)[C@@]5([C@](C[C@@]4(C(=O)[C@@H]3O)[H])(O5)[H])[H])[H])[H])([C@@H](OC(C)=O)[C@@]6([C@@]2([C@H](C)C=C7[C@]6(C)[C@](C)(O)C(=O)O7)[H])[H])[H]
Synonyms:- Taccalonolide A
- 16,24-Cycloergost-22-en-26-oic acid, 1,11,12,15-tetrakis(acetyloxy)-2,3-epoxy-7,23,25-trihydroxy-6-oxo-, γ-lactone, (1α,2α,3α,5α,7β,11α,12α,15α,16β,24β,25S)-
- 15-O-Acetyltaccalonolide B
- Taccalonolide
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Found 5 products.
Taccalonolide A
CAS:Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it isFormula:C36H46O14Purity:98.16% - 99.4%Color and Shape:SolidMolecular weight:702.74Taccalonolide A
CAS:<p>Taccalonolide A is a novel compound that has been shown to have clonogenic and radioprotective properties in vitro. Taccalonolide A has been shown to inhibit the proliferation of tumor cells and induce apoptosis, with an IC50 of 3.5 μM in a human breast cancer cell line. Taccalonolide A also inhibits the inflammatory response in an animal model of colitis. This activity may be due to its ability to inhibit NF-κB and STAT3 signaling pathways, which are involved in the regulation of inflammation. The two main chemical structures found in Taccalonolide A are taxanes and plantagines, which are used as anti-tumor drugs.</p>Formula:C36H46O14Purity:Min. 95%Molecular weight:702.75 g/mol
