CAS 1092351-67-1

Torkinib

Description:

Torkinib, with the CAS number 1092351-67-1, is a small molecule that functions primarily as a selective inhibitor of certain kinases, particularly those involved in signaling pathways related to cancer cell proliferation and survival. It is characterized by its ability to interfere with the activity of specific enzymes, thereby modulating cellular processes such as growth, differentiation, and apoptosis. Torkinib has been studied for its potential therapeutic applications in oncology, particularly in the treatment of various types of tumors that exhibit aberrant kinase activity. The compound's chemical structure typically includes functional groups that enhance its binding affinity to target proteins, contributing to its efficacy as an inhibitor. Additionally, its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are crucial for determining its suitability for clinical use. As with many targeted therapies, ongoing research aims to elucidate its full spectrum of biological effects and potential side effects, ensuring a comprehensive understanding of its role in cancer treatment.

Formula: C₁₆H₁₆N₆O

InChI: InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)

InChI key: InChIKey=MFAQYJIYDMLAIM-UHFFFAOYSA-N

SMILES: NC1=C2C(=NN(C(C)C)C2=NC=N1)C3=CC=4C(N3)=CC=C(O)C4

Synonyms:

• 1H-Indol-5-ol, 2-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-
• 2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
• 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
• Pp242
• Torkinib
• PP 242
• Torkinib (PP242)
• CS-19
• PP242 (Torkinib)
• PP242, Free Base
• PP242, >=98%
• PP242 USP/EP/BP
• 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol PP 242
• (2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol
• pp242, 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
• TORKINIB;PP242; PP-242;PP 242
• 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol/PP242

PP242

CAS: 1092351-67-1

Formula: C₁₆H₁₆N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 308.3378

Ref: IN-DA008SSC

Torkinib

CAS: 1092351-67-1

Torkinib

Purity: ≥98%

Molecular weight: 308.34g/mol

Ref: 54-BUP15517

Torkinib

CAS: 1092351-67-1

Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).

Formula: C₁₆H₁₆N₆O

Purity: 99.11%

Color and Shape: Solid

Molecular weight: 308.34

Ref: TM-T2414

PP242

CAS: 1092351-67-1

Purity: ≥ 95.0%

Color and Shape: White to off-white solid

Ref: 7W-GW9275

PP242

CAS: 1092351-67-1

PP242

Formula: C₁₆H₁₆N₆O

Purity: 99.60% (Typical Value in Batch COA)

Color and Shape: yellow solid

Molecular weight: 308.34g/mol

Ref: 54-BIFK0004

Torkinib (PP242)

CAS: 1092351-67-1

Torkinib is a matrix-effect inhibitor that inhibits the activity of the mTOR protein. It was initially developed for the treatment of bowel disease, but has been shown to be effective in inhibiting cancer cells as well. Torkinib prevents cell growth by binding to the cytosolic C2 domain and thus preventing activation of cyclic AMP (cAMP). The drug also inhibits hyperproliferative diseases such as psoriasis and cancer by binding to rapamycin and other proteins in an effort to inhibit mTOR activity. Torkinib is used in conjunction with other agents, including rapamycin, for treating cancers such as pancreatic, breast, prostate, colorectal, lung and head and neck cancers. Torkinib may have a more potent effect on cancer cells than on normal cells due to its ability to inhibit the protein polymerase chain reaction (PCR) process. This inhibition prevents DNA replication and protein synthesis from occurring which leads to

Formula: C₁₆H₁₆N₆O

Purity: Min. 95%

Molecular weight: 308.34 g/mol

Ref: 3D-STB35167