CAS 1092364-38-9

Poziotinib

Description:

Poziotinib is a small molecule tyrosine kinase inhibitor primarily developed for the treatment of certain types of cancer, particularly non-small cell lung cancer (NSCLC) with specific genetic mutations. It selectively targets the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), which are often implicated in tumor growth and proliferation. The compound is characterized by its ability to inhibit both wild-type and mutant forms of these receptors, making it a potential therapeutic option for patients with resistance to other treatments. Poziotinib is typically administered orally and has been evaluated in clinical trials for its efficacy and safety profile. Its chemical structure includes a quinazoline core, which is common among many kinase inhibitors, and it exhibits properties that allow for effective binding to the target receptors. As with many targeted therapies, monitoring for side effects and drug interactions is essential during treatment. Overall, Poziotinib represents a promising approach in the evolving landscape of targeted cancer therapies.

Formula: C₂₃H₂₁Cl₂FN₄O₃

InChI: InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

InChI key: InChIKey=LPFWVDIFUFFKJU-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OC)C(OC3CCN(C(C=C)=O)CC3)=C2)N=CN1)C4=C(F)C(Cl)=C(Cl)C=C4

Synonyms:

• 1-[4-[4-(3,4-Dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
• 2-Propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-
• Poziotinib
• 1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one
• HM781-36B)
• NOV120101
• UNII-OEI6OOU6IK
• 1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one Poziotinib
• 1-(4-((4-((3,4-dichloro-2-fluorophenyl)aMino)-7- Methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one
• Poziotinib(NOV120101
• poziotinib(HM-78136B)

1-[4-[[4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one

CAS: 1092364-38-9

Formula: C₂₃H₂₁Cl₂FN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 491.3422

Ref: IN-DA0039LB

Poziotinib

CAS: 1092364-38-9

Poziotinib

Purity: 97%

Molecular weight: 491.34g/mol

Ref: 54-PC108644

Poziotinib

CAS: 1092364-38-9

Poziotinib

Purity: ≥95%

Molecular weight: 491.34g/mol

Ref: 54-BUP03375

Poziotinib

CAS: 1092364-38-9

Poziotinib (NOV120101)(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).

Formula: C₂₃H₂₁Cl₂FN₄O₃

Purity: 98.69% - 99.78%

Color and Shape: Solid

Molecular weight: 491.34

Ref: TM-T2630

Poziotinib

Controlled Product

CAS: 1092364-38-9

Formula: C₂₃H₂₁Cl₂FN₄O₃

Color and Shape: Neat

Molecular weight: 491.34

Ref: TR-P215770

Poziotinib

CAS: 1092364-38-9

Inhibitor of EGFR receptor

Formula: C₂₃H₂₁Cl₂FN₄O₃

Purity: Min. 95%

Molecular weight: 491.34 g/mol

Ref: 3D-BP161454