CAS 1092538-80-1

SAR131675

Controlled Product

CAS: 1092538-80-1

Applications SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD.
References Alam, A., et al.: Mol. Cancer. Ther., 11, 1637 (2012);

Formula: C₁₈H₂₂N₄O₄

Color and Shape: Neat

Molecular weight: 358.39

Ref: TR-S139510

SAR131675

CAS: 1092538-80-1

SAR131675 is a small molecule that potently inhibits angiotensin converting enzyme (ACE) and angiotensin receptor type 1 (AT1). SAR131675 selectively blocks the kinase activity of ACE, thereby inhibiting the production of Ang II. This drug has shown anticancer activity in vitro by inducing apoptosis in cancer cells. SAR131675 also has anti-herpes simplex virus activity, which may be due to its ability to inhibit viral DNA synthesis and/or stimulate cell death.

Formula: C₁₈H₂₂N₄O₄

Purity: Min. 95%

Molecular weight: 358.4 g/mol

Ref: 3D-STB53880