CAS 109333-26-8

D-arg(hyp3,D-phe7)-bradykinin

Description:

D-arg(hyp3,D-phe7)-bradykinin, also known as a synthetic analog of bradykinin, is a peptide that exhibits potent biological activity, particularly in the modulation of blood pressure and inflammatory responses. This compound is characterized by its specific amino acid substitutions, which enhance its stability and receptor affinity compared to natural bradykinin. The presence of D-arginine and D-phenylalanine in its structure contributes to its resistance to enzymatic degradation, making it a valuable tool in pharmacological research. D-arg(hyp3,D-phe7)-bradykinin primarily interacts with bradykinin receptors, influencing vasodilation and pain signaling pathways. Its applications extend to studies in cardiovascular physiology and potential therapeutic interventions for conditions like hypertension and pain management. The compound is typically synthesized through solid-phase peptide synthesis and is utilized in various experimental settings to explore its pharmacodynamics and pharmacokinetics. Overall, its unique structural modifications provide insights into peptide design for enhanced biological activity.

Formula: C₆₀H₈₇N₁₉O₁₃

InChI: InChI=1/C60H87N19O13/c61-39(20-10-24-68-58(62)63)49(83)73-40(21-11-25-69-59(64)65)55(89)78-27-13-23-46(78)56(90)79-33-38(81)31-47(79)54(88)71-32-48(82)72-42(28-35-14-4-1-5-15-35)50(84)77-45(34-80)53(87)76-44(30-37-18-8-3-9-19-37)52(86)75-43(29-36-16-6-2-7-17-36)51(85)74-41(57(91)92)22-12-26-70-60(66)67/h1-9,14-19,38-47,80-81H,10-13,20-34,61H2,(H,71,88)(H,72,82)(H,73,83)(H,74,85)(H,75,86)(H,76,87)(H,77,84)(H,91,92)(H4,62,63,68)(H4,64,65,69)(H4,66,67,70)/t38-,39-,40+,41+,42+,43+,44-,45+,46+,47+/m1/s1

Synonyms:

• Npc 567
• Arg-3-hyp-7-phe-bradykinin
• Bradykinin, arg(0)-hyp(3)-phe(7)-
• Bradykinin, arg-hyp(3)-phe(7)-
• Bradykinin, arginyl-hydroxyprolyl(3)-phenylalanine(7)-
• Bradykinin, N2-D-arginyl-3-(trans-4-hydroxy-L-proline)-7-D-phenylalanine-
• N~5~-(diaminomethylidene)-D-ornithyl-N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithine
• (D-Arg0,Hyp3,D-Phe7)-Bradykinin
• H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH

2-methylpent-2-enal

CAS: 109333-26-8

2-methylpent-2-enal

Molecular weight: 98.14g/mol

Ref: 54-BUP20396

NPC 567

CAS: 109333-26-8

NPC 567 is an antagonist of the bradykinin receptor.

Formula: C₆₀H₈₇N₁₉O₁₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 1282.48

Ref: TM-T21060

(D-Arg0, Hyp 3,D-Phe7)-Bradykinin trifluoroacetate salt

CAS: 109333-26-8

Bradykinin is a peptide hormone that has been found to act through the bradykinin receptor. It has also been found to be an antagonist of the receptor, as it inhibits the growth of cells that are stimulated by bradykinin. This drug can be used for the treatment of asthma and other inflammatory diseases. The sequence of this drug is D-Arg0, Hyp 3,D-Phe7)-Bradykinin trifluoroacetate salt H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH trifluoroacetate salt.

Formula: C₆₀H₈₇N₁₉O₁₃

Purity: Min. 95%

Molecular weight: 1,282.45 g/mol

Ref: 3D-FA109821