CAS 109358-46-5

Boc-Leu-Arg-Arg-AMC . 2 HCl

Description:

Boc-Leu-Arg-Arg-AMC·2 HCl, also known as a peptide substrate, is a synthetic compound commonly used in biochemical research, particularly in studies involving proteases and enzyme activity. The "Boc" (tert-butyloxycarbonyl) group serves as a protective group for the amino acid leucine (Leu), while "Arg" denotes arginine residues, which are known for their basic properties and involvement in various biological processes. The "AMC" (7-amino-4-methylcoumarin) moiety acts as a fluorescent reporter, allowing for the detection of enzymatic cleavage. The presence of two hydrochloride (HCl) salts indicates that the compound is in a salt form, which can enhance its solubility in aqueous solutions. This compound is typically utilized in assays to monitor proteolytic activity, as the cleavage of the peptide bond releases the fluorescent AMC, enabling quantitative analysis. Its stability, solubility, and fluorescent properties make it a valuable tool in molecular biology and biochemistry for studying enzyme kinetics and substrate specificity.

Boc-Leu-Arg-Arg-AMC · 2 HCl

CAS: 109358-46-5

Boc-LLR-AMC is a good substrate for the Kex2 endoprotease (kexin, previously known as proteinase yscF), a membrane-bound, calcium-dependent serine protease from yeast α-cells. Boc-LRR-AMC is also used for determining the trypsin-like activity of the proteasome.

Formula: C₃₃H₅₂N₁₀O₇·2HCl

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 773.76

Ref: 01-4017087

Boc-LRR-AMC

CAS: 109358-46-5

Boc-LRR-AMC is a fluorogenic 26S/20S proteasome substrate that releases fluorescent AMC upon cleavage, aiding activity quantification.

Formula: C₃₃H₅₂N₁₀O₇

Color and Shape: Solid

Molecular weight: 700.83

Ref: TM-T37011

Boc-Leu-Arg-Arg-AMC

CAS: 109358-46-5

Formula: C₃₃H₅₂N₁₀O₇·C₂H₄O₂

Purity: ≥ 98.0%

Color and Shape: White lyophilised powder

Molecular weight: 760.9

Ref: 7W-GL3169

Boc-Leu-Arg-Arg-AMC·2 HCl

Controlled Product

CAS: 109358-46-5

Formula: C₃₃H₅₂N₁₀O₇

Color and Shape: Neat

Molecular weight: 700.829

Ref: TR-B015266

Boc-Leu-Arg-Arg-AMC dihydrochloride

CAS: 109358-46-5

Boc-Leu-Arg-Arg-AMC·2 HCl is a soybean trypsin inhibitor that has been used in the study of basic protein synthesis and cellular physiology. This inhibitor binds to the active site of soybean trypsin, preventing it from cleaving peptide bonds. The kinetic of this reaction was studied using Boc-Leu-Arg-Arg-AMC·2 HCl as a substrate and its inhibition by various concentrations of inhibitors. The inhibitory effect on the enzyme activity was measured by following the release of AMC fluorogenic substrate in vitro. Boc-Leu-Arg-Arg-AMC·2 HCl was found to be an effective inhibitor of melanoma antigen formation in vivo when injected into mice with melanoma xenografts. It also decreased tumor growth and increased survival rates in leukemic mice treated with platinum chemotherapy drugs or other pharmacological agents.

Formula: C₃₃H₅₂N₁₀O₇·2HCl

Purity: Min. 95%

Molecular weight: 773.75 g/mol

Ref: 3D-FB110557

Boc-Leu-Arg-Arg-AMC

CAS: 109358-46-5

Boc-Leu-Arg-Arg-AMC is a synthetic, nonpeptide antagonist of the CGRP receptor. It has been shown to inhibit the binding of peptides to the CGRP receptor and is used as a research tool for studying the pharmacology and protein interactions of this receptor. Boc-Leu-Arg-Arg-AMC has been shown to stimulate ion channel activity in vitro. This compound also has an affinity for antibodies that are specific for CGRP receptors, which can be used as a ligand in immunoassays.

Formula: C₃₃H₅₂N₁₀O₇

Purity: Min. 95%

Molecular weight: 700.83 g/mol

Ref: 3D-MLR-3140-V