CAS 1093659-89-2

EzetiMibe-d4

Description:

EzetiMibe-d4 is a deuterated form of ezetimibe, a medication primarily used to lower cholesterol levels by inhibiting the absorption of cholesterol in the intestines. The deuterated version, indicated by the "d4" in its name, contains four deuterium atoms, which are isotopes of hydrogen. This modification can enhance the substance's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in metabolic studies and drug development. The chemical structure of ezetimibe-d4 retains the core characteristics of ezetimibe, including its ability to selectively inhibit the Niemann-Pick C1-like 1 (NPC1L1) protein, which plays a crucial role in cholesterol absorption. As a research compound, ezetimibe-d4 is valuable for tracing and quantifying the drug's metabolic pathways in biological systems. Its CAS number, 1093659-89-2, uniquely identifies this specific deuterated compound in chemical databases, facilitating its use in scientific literature and regulatory contexts.

Formula: C₂₄H₂₁F₂NO₃

Synonyms:

• Ezetimibe Impurity 119
• (3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one
• Ezetimibe D4
• Ezetimibe D4 Q: What is the storage condition of
• Ezetimibe D4Q: What is
• [2H4]-Ezetimibe
• Ezetimibe D4 Q: What is the CAS Number of

Ezetimibe-d4-1

CAS: 1093659-89-2

Ezetimibe-d4-1 is the deuterated form of Ezetimibe, which functions as a potent cholesterol absorption inhibitor and NPC1L1 inhibitor, and also exhibits Nrf2 activation properties.

Formula: C₂₄H₂₁F₂NO₃

Color and Shape: Solid

Molecular weight: 413.45

Ref: TM-T203710

Ezetimibe-d4

CAS: 1093659-89-2

Formula: C₂₄H₁₇D₄F₂NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 413.46

Ref: 4Z-E-061

Ezetimibe Impurity 105

CAS: 1093659-89-2

Formula: C₃₉H₄₆F₂N₂O₅Si₂

Molecular weight: 716.97

Ref: 4Z-E-06145

Ezetimibe-d4

Controlled Product

CAS: 1093659-89-2

Applications Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.
References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Formula: C₂₄D₄H₁₇F₂NO₃

Color and Shape: Neat

Molecular weight: 413.45

Ref: TR-E975003

Ezetimibe-d4

CAS: 1093659-89-2

Ezetimibe-d4 is a reference standard for pharmacokinetic bioanalysis, which is used to validate analytical methods for the determination of ezetimibe in plasma. Ezetimibe-d4 is prepared by isotopic dilution, and its purity and potency are determined by high-performance liquid chromatography (HPLC) and mass spectrometry. The analyte can be detected in plasma samples that are collected orally. Analytical methods that use this reference material will have an abscissa of 0.5 to 1.5 hours post-dose, with a regression line that has a slope of -1/2 to -1/6 and an intercept at the origin.

Formula: C₂₄H₂₁F₂NO₃

Purity: Min. 95%

Molecular weight: 413.4 g/mol

Ref: 3D-TTB65989