CAS 1093659-90-5

EZETIMIBE-D4

Description:

EZETIMIBE-D4 is a deuterated form of ezetimibe, a medication primarily used to lower cholesterol levels by inhibiting the absorption of cholesterol in the intestines. The "D4" designation indicates that this compound contains four deuterium atoms, which are isotopes of hydrogen, replacing the regular hydrogen atoms in the ezetimibe structure. This modification can be useful in pharmacokinetic studies and metabolic research, as it allows for the tracking of the compound in biological systems. EZETIMIBE-D4 retains the core characteristics of ezetimibe, including its mechanism of action as a selective inhibitor of the Niemann-Pick C1-like 1 (NPC1L1) protein, which plays a crucial role in cholesterol transport. The compound is typically used in research settings to study the metabolism and pharmacodynamics of ezetimibe without interference from the natural hydrogen isotopes. As with any chemical substance, proper handling and safety precautions should be observed, particularly in laboratory environments.

Formula: C₂₄H₁₇D₄F₂NO₃

InChI: InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1/i7D,8D,9D,10D

InChI key: InChIKey=OLNTVTPDXPETLC-ARVCERDTSA-N

SMILES: C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=C(C(=C(F)C(=C3[2H])[2H])[2H])[2H])C4=CC=C(O)C=C4

Synonyms:

• (3R,4S)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-(2,3,5,6-tetradeuterio-4-fluorophenyl)azetidin-2-one
• (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone-d4
• EZETIMIBE-D4

Ezetimibe-d4 [N-(4-fluoro-phenyl-d4)]

CAS: 1093659-90-5

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 413.46

Ref: 3U-D7529

Ezetimibe-d4

CAS: 1093659-90-5

Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation

Formula: C₂₄H₂₁F₂NO₃

Purity: 98%

Color and Shape: White Solid

Molecular weight: 413.45

Ref: TM-T11250

Ezetimibe-d4 (on N-Benzene ring)

CAS: 1093659-90-5

Formula: C₂₄H₁₇D₄F₂NO₃

Molecular weight: 413.46

Ref: 4Z-E-06158

(3R,4S)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-(2,3,5,6-tetradeuterio-4-fluorophenyl)azetidin-2-one

Controlled Product

CAS: 1093659-90-5

Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.
References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Formula: C₂₄₂H₄H₁₇F₂NO₃

Color and Shape: Neat

Molecular weight: 413.45

Ref: TR-E975002

Ezetimibe-d4

CAS: 1093659-90-5

Ezetimibe-d4 is a lipophilic, organo-metal chelator that has been used to assess the bioavailability of drugs in pharmacokinetic studies. Ezetimibe-d4 binds to the metal ion in the gastrointestinal tract and prevents it from being absorbed into the blood stream. The ability to bind with metals such as nickel and gallium makes it an ideal candidate for use in analytical methods such as LC-MS/MS. In addition, ezetimibe has been shown to be effective in reducing insulin sensitivity and may be a viable treatment for diabetes.

Formula: C₂₄H₂₁F₂NO₃

Purity: Min. 95%

Molecular weight: 413.4 g/mol

Ref: 3D-TTB65990