CAS 1093861-60-9: Afoxolaner

Description: Afoxolaner is an insecticide and acaricide belonging to the isoxazoline class of compounds, primarily used in veterinary medicine for the treatment and prevention of flea and tick infestations in dogs and cats. Its mechanism of action involves the inhibition of gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels, leading to paralysis and death of the target parasites. Afoxolaner is characterized by its high efficacy against a broad spectrum of ectoparasites, including fleas, ticks, and mites, and is typically administered orally in the form of chewable tablets. The compound is known for its long-lasting effects, providing protection for several weeks after administration. Afoxolaner is generally well-tolerated in pets, with a low incidence of adverse effects. Its safety profile, combined with its effectiveness, has made it a popular choice among veterinarians for managing parasitic infestations. As with any pharmaceutical, it is important to follow dosage guidelines and consult a veterinarian for appropriate use.

Formula: C₂₆H₁₇ClF₉N₃O₃

InChI: InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)

InChI key: InChIKey=OXDDDHGGRFRLEE-UHFFFAOYSA-N

SMILES: O=C(NCC(=O)NCC(F)(F)F)C=1C=CC(=C2C=CC=CC12)C3=NOC(C=4C=C(Cl)C=C(C4)C(F)(F)F)(C3)C(F)(F)F

Synonyms:

• 4-[5-(3-chloro-5-trifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalene-1-carboxylic acid [(2,2,2-trifluoroethylcarbamoyl)-methyl]-amide
• 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
• 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
• 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
• Afoxolaner
• Nexgard

4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

CAS: 1093861-60-9

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 625.8701

Afoxolaner

CAS: 1093861-60-9

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Purity: 99.10% - 99.38%
• Color and Shape: Solid
• Molecular weight: 625.87

Afoxolaner

CAS: 1093861-60-9

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 625.88

Afoxolaner-d6

CAS: 1093861-60-9

• Formula: C₂₆H₁₁D₆ClF₉N₃O₃
• Molecular weight: 631.91

Afoxolaner

CAS: 1093861-60-9

• Purity: 99.09%
• Molecular weight: 625.87g/mol

Afoxolaner

CAS: 1093861-60-9

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Color and Shape: Neat
• Molecular weight: 625.87

Afoxolaner

CAS: 1093861-60-9

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Color and Shape: Neat
• Molecular weight: 625.87

Afoxolaner 100 µg/mL in Acetonitrile

CAS: 1093861-60-9

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Color and Shape: Single Solution
• Molecular weight: 625.87

Afoxolaner

CAS: 1093861-60-9

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• Formula: C₂₆H₁₇ClF₉N₃O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 625.87 g/mol

Afoxolaner

CAS: 1093861-60-9

• Formula: C₂₆H₁₇ClF₉N₃O₃
• Color and Shape: Colourless
• Molecular weight: 625.87