CAS 109423-03-2

(11β,16α)-11,21-Dihydroxy-16,17-[(2-hydroxybutylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Description:

The chemical substance known as (11β,16α)-11,21-Dihydroxy-16,17-[(2-hydroxybutylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, with the CAS number 109423-03-2, is a synthetic steroid compound that exhibits glucocorticoid activity. It is characterized by the presence of multiple hydroxyl groups, which contribute to its biological activity and solubility properties. The structure features a pregnane backbone, typical of steroid hormones, with specific modifications that enhance its pharmacological profile. This compound is often studied for its potential therapeutic applications, particularly in the treatment of inflammatory and autoimmune conditions, due to its ability to modulate immune responses. Its unique functional groups, including the hydroxybutylidene moiety, may influence its interaction with biological targets, such as glucocorticoid receptors. Overall, this compound represents a class of steroids that are important in medicinal chemistry and pharmacology, with ongoing research into their efficacy and safety profiles.

Formula: C₂₅H₃₄O₇

InChI: InChI=1S/C25H34O7/c1-4-17(28)22-31-20-10-16-15-6-5-13-9-14(27)7-8-23(13,2)21(15)18(29)11-24(16,3)25(20,32-22)19(30)12-26/h7-9,15-18,20-22,26,28-29H,4-6,10-12H2,1-3H3/t15-,16-,17?,18-,20+,21+,22?,23-,24-,25+/m0/s1

InChI key: InChIKey=OBFKEHNWUXWRPI-BZGQYQIDSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C(CC)O)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]

Synonyms:

• (11β,16α)-11,21-Dihydroxy-16,17-[(2-hydroxybutylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 23-Hydroxybudesonide
• Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(2-hydroxybutylidene)bis(oxy)]-, (11β,16α)-

23-Hydroxy Budesonide (Mixture of Diastereomers)

CAS: 109423-03-2

Formula: C₂₅H₃₄O₇

Color and Shape: White To Off-White Solid

Molecular weight: 446.54

Ref: 4Z-B-0315

23-Hydroxybudesonide

Controlled Product

CAS: 109423-03-2

Applications 23-Hydroxybudesonide is an metabolite of budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent.
References Edsbaecker, S., et al.: Drug. Metabol. Dispostion., 15, 403 (1987); Moore, C.D., et al.: Drug. Metabolism. Disposition., 41, 379 (2013);

Formula: C₂₅H₃₄O₇

Color and Shape: Neat

Molecular weight: 446.53

Ref: TR-H830360

23-Hydroxy Budesonide

CAS: 109423-03-2

Formula: C₂₅H₃₄O₇

Molecular weight: 446.54

Ref: ST-EA-CP-B19025