CAS 109425-51-6

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine

Description:

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine, commonly referred to as Fmoc-His(Trt)-OH, is a protected derivative of the amino acid histidine, primarily used in peptide synthesis. This compound features a fluorenylmethoxycarbonyl (Fmoc) group, which serves as a protective group for the amino functionality, allowing for selective reactions during peptide assembly. The triphenylmethyl (Trt) group protects the side chain of histidine, specifically the imidazole nitrogen, preventing unwanted reactions. The presence of these protective groups enhances the stability and solubility of the compound in organic solvents, making it suitable for solid-phase peptide synthesis. Fmoc-His(Trt)-OH is characterized by its relatively high molecular weight and complex structure, which contributes to its utility in synthesizing peptides with specific sequences and functionalities. Additionally, the compound is typically stable under standard laboratory conditions but may require specific conditions for deprotection and subsequent reactions. Its applications extend to biochemistry and pharmaceutical research, particularly in the development of peptide-based therapeutics.

Formula: C₄₀H₃₃N₃O₄

InChI: InChI=1S/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-43(27-41-31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/t37-/m0/s1

InChI key: InChIKey=XXMYDXUIZKNHDT-QNGWXLTQSA-N

SMILES: C(N1C=C(C[C@H](NC(OCC2C=3C(C=4C2=CC=CC4)=CC=CC3)=O)C(O)=O)N=C1)(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

Synonyms:

• (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
• (2S)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
• (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(1-trityl-1H-imidazol-5-yl)propanoate
• <span class="text-smallcaps">L</span>-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-
• Fmoc-His(Trt)-OH
• Fmoc-L-His(Trt)-OH
• N(alpha)-fmoc-N(im)-trityl-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine
• N-Fmoc-N'-trityl-L-histidine
• N-[(9H-Fluoren-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-<span class="text-smallcaps">L</span>-histidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-tritylhistidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-trityl-L-histidine
• N-alpha-(9-fluorenylmethyloxycarbonyl)-N-im-trityl-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine

Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine

CAS: 109425-51-6

Formula: C₄₀H₃₃N₃O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 619.72

Ref: 3B-F0653

N-Fmoc-1-trityl-L-histidine, 98%

CAS: 109425-51-6

It is used in the synthesis and application of Fmoc-His(3-Bum)-OH. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU refere

Formula: C₄₀H₃₃N₃O₄

Purity: 98%

Molecular weight: 619.72

Ref: 02-H59711

Fmoc-His(1-Trt)-OH

CAS: 109425-51-6

As to minimize racemization, Fmoc-His(Trt)-OH is best coupled with DEPBT.

Formula: C₄₀H₃₃N₃O₄

Purity: 99.69%

Color and Shape: White

Molecular weight: 619.72

Ref: 01-4011444

N-Fmoc-N‘-Trityl-L-Histidine

CAS: 109425-51-6

Formula: C₄₀H₃₃N₃O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 619.7077

Ref: IN-DA0037YN

Fmoc-his(trt)-oh

CAS: 109425-51-6

Fmoc-his(trt)-oh

Formula: C₄₀H₃₃N₃O₄

Purity: 98%

Color and Shape: white solid

Molecular weight: 619.71g/mol

Ref: 54-OR925829

Fmoc-His(Trt)-OH

CAS: 109425-51-6

Formula: C₄₀H₃₃N₃O₄

Purity: ≥ 99.0%

Color and Shape: White to almost white powder

Molecular weight: 619.71

Ref: 7W-GM2917

Fmoc-His(Trt)-OH

CAS: 109425-51-6

M03415 - Fmoc-His(Trt)-OH

Formula: C₄₀H₃₃N₃O₄

Purity: 98%

Color and Shape: Crystalline Powder,Powder

Molecular weight: 619.721

Ref: 10-M03415

Fmoc-His(Trt)-OH

CAS: 109425-51-6

Fmoc-His(Trt)-OH is a synthetic compound for peptide synthesis, functionalization, and chemical biology studies.

Formula: C₄₀H₃₃N₃O₄

Purity: 97.97%

Molecular weight: 619.72

Ref: TM-T67561

Fmoc-His(Trt)-OH

CAS: 109425-51-6

Fmoc-His(Trt)-OH is an amino acid with the chemical formula HOOC-CH2-CH2-N(CH3)2. It has broad-spectrum antimicrobial activity and can be used as a chemosensor for trifluoroacetic acid. Fmoc-His(Trt)-OH also showed anticancer activity, which may be due to its ability to inhibit protein synthesis in cancer cells by inhibiting histidine decarboxylase. Fmoc-His(Trt)-OH is synthesized through a chemical reaction using trifluoroacetic acid, which reacts with His and Trt residues on the surface of the resin.

Formula: C₄₀H₃₃N₃O₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 619.71 g/mol

Ref: 3D-FF15882

Na-FMOC-N(im)-Trityl-L-Histidine (FMOC-His(Trt)-OH) extrapure, 99%

CAS: 109425-51-6

Formula: C₄₀H₃₃N₃O₄

Purity: min. 99%

Color and Shape: White to off-white, Powder

Molecular weight: 619.71

Ref: SR-36877

Fmoc-His(Trt)-OH

CAS: 109425-51-6

Formula: C₄₀H₃₃N₃O₄

Molecular weight: 619.7

Ref: ST-EA-CP-L28029