CAS 109434-24-4

N(alpha)-fmoc-N(im)-trityl-L-histidine pentafluorophe.ester

Description:

N(alpha)-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester is a protected derivative of the amino acid histidine, commonly used in peptide synthesis and research. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions without interfering with the side chain. The trityl group provides additional protection for the imidazole side chain of histidine, enhancing stability during synthesis. The pentafluorophenyl ester moiety is a reactive group that facilitates the coupling of this compound to other amino acids or peptides, making it valuable in solid-phase peptide synthesis. This compound is characterized by its relatively high stability under standard conditions, but it can be deprotected under specific conditions to yield the active histidine residue. Its unique structure allows for the introduction of histidine into peptides while maintaining the integrity of the side chain, which is crucial for biological activity and function. Overall, this compound is significant in the field of biochemistry and medicinal chemistry for the synthesis of complex peptides.

Formula: C₄₆H₃₂F₅N₃O₄

InChI: InChI=1/C46H32F5N3O4/c47-38-39(48)41(50)43(42(51)40(38)49)58-44(55)37(53-45(56)57-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-54(27-52-31)46(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,53,56)/t37-/m0/s1

SMILES: c1ccc(cc1)C(c1ccccc1)(c1ccccc1)n1cc(C[C@@H](C(=O)Oc2c(c(c(c(c2F)F)F)F)F)N=C(O)OCC2c3ccccc3c3ccccc23)nc1

Synonyms:

• Fmoc-His(Trt)-OPfp
• N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester
• (2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoate
• FMOC-HISTIDINE(1-TRT)-OPFP
• -Trityl-L-histidine pentafluorophenyl ester
• FMOC-HIS(T-TRT)-OPFP
• N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IM-TRITYL-L-HISTIDINE PENTAFLUORPHENYL ESTER
• L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-, 2,3,4,5,6-pentafluorophenyl ester
• (S)-Perfluorophenyl 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1-trityl-1H-iMidazol-4-yl)propanoate
• N-ALPHA-FMOC-N(IM)-TRITYL-L-HISTIDINE PENTAFLUOROPHENYL ESTER
• Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester
• NA-FMOC-NIM-TRITYL-L-HISTIDINE*PENTAFLUO ROPHENYL ES
• (9H-Fluoren-9-yl)MethOxy]Carbonyl His(Trt)-OPfp
• N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester USP/EP/BP
• FMOC-N-IM-TRITYL-L-HISTIDINE PENTAFLUOROPHENYL ESTER
• L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-, pentafluorophenyl ester (9CI)
• NALPHA-9-Fluorenylmethoxycarbonyl-Nim-trityl-L-histidine pentafluorophenyl
• L-Histidine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• 2,3,4,5,6-pentafluorophenyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate
• N(alpha)-fmoc-N(im)-trityl-L-histidine pentafluorophe.ester
• Nα-(9-Fluorenylmethoxycarbonyl)-N(IM)-trityl-L-histidine pentafluorophenyl ester ,98%
• Fmoc-His(tau-Trt)-OPfp
• FMOC-HIS(1-TRT)-OPFP
• nα-fmoc-n(im)-trityl-l-histidine pentafluorophenyl ester
• FMOC-L-HIS(TRT)-OPFP

Fmoc-His(1-Trt)-OPfp

CAS: 109434-24-4

Fmoc-His(Trt)-OPfp contains cyclohexane and pentafluorophenol (1 mol) from crystallization.

Formula: C₄₆H₃₂F₅N₃O₄

Purity: > 90%

Color and Shape: White Powder

Molecular weight: 785.77

Ref: 01-4011864

Fmoc-His(Trt)-Opfp

CAS: 109434-24-4

Formula: C₄₆H₃₂F₅N₃O₄

Color and Shape: Solid

Molecular weight: 785.7560

Ref: IN-DA003CO7

Fmoc-His(Trt)-OPfp

CAS: 109434-24-4

Molecular weight: 785.76

Ref: 7W-GM8311

Fmoc-His(Trt)-OPfp

CAS: 109434-24-4

Fmoc-His(Trt)-OPfp

Purity: ≥95%

Molecular weight: 785.76g/mol

Ref: 54-PC48017

Fmoc-His(Trt)-OPfp

CAS: 109434-24-4

Fmoc-His(Trt)-OPfp is a glycoprotein that can be used to produce monoclonal antibodies. It is synthetically produced and contains an L-amino acid at the N-terminus and a peptide with an oligopeptide sequence at the C-terminus. The lysine residue of this glycoprotein is used as a positional marker in the production of monoclonal antibodies. Fmoc-His(Trt)-OPfp has been shown to have high affinity for mucin and can be used to produce specific monoclonal antibodies, which are immunoglobulin molecules that bind to a single antigen.

Formula: C₄₆H₃₂N₃O₄F₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 785.76 g/mol

Ref: 3D-FF72188